Botanical species · safety record

Coleus forskohlii

The EFSA Compendium of Botanicals holds 10 constituent measurements and 1 adverse-effect record for Coleus forskohlii. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Coleus forskohlii (Willd.) Briq.

10Constituent measurements

1Safety records

6Cited sources

32Licensed products (Canada)

Also recorded as

Plectranthus barbatus Andr.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 32 licensed products naming Coleus forskohlii as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Leaf
Root
Root (standardized extract)
Root extract
Root extract (standardised)
leaf standardized extract

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Leaves	Solvent extraction	—	Phytochemical screening	Resolve DOI
Coumarins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Forskolin	Roots and other underground parts	Super-critical gas extraction	≥ 20 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Forskolin	Roots and other underground parts	Super-critical gas extraction	≤ 30 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Labdane diterpenes	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Forskolin	Aerial part of plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Forskolin	Roots and other underground parts	Solvent extraction	0.3 Percent	LC-MS	No resolvable identifier
Forskolin	Stem / stalk	Solvent extraction	0.03 Percent	LC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Roots and other underground parts	Super-critical gas extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Virgona, Nantiga., Taki, Yuko., Yamada, Shizuo., Umegaki, Keizo. Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice . Journal of applied toxicology, 2013, vol. 33, no. 9, p. 924-932. DOI
Bodiwala, Hardik S., Sabde, Sudeep., Mitra, Debashis., Bhutani, Kamlesh Kumar., Singh, Inder Pal. Anti-MV Diterpenes from Coleus forskohlii. Natural product communications, 2009, vol. 4, no. 9, p. 1173-1175.
Schaneberg, BT., Khan, IA. Quantitative analysis of forskolin in Coleus forskohlii (Lamiaceae) by reversed-phase liquid chromatography . Journal of aoac international, 2003, vol. 86, no. 3, p. 467-470.
Takshak, Swabha., Agrawal, S. B. The role of supplemental ultraviolet-B radiation in altering the metabolite profile, essential oil content and composition, and free radical scavenging activities of Coleus forskohlii, an indigenous medicinal plant . Environmental science and pollution research, 2016, vol. 23, no. 8, p. 7324-7337. DOI
Khatun, Selima., Cakilcioglu, Ugur., Chatterjee, Narayan Chandra. Phytochemical constituents vis-a-vis histochemical localization of forskolin in a medicinal plant Coleus forskohlii Briq. . Journal of medicinal plants research, 2011, vol. 5, no. 5, p. 711-718.
ROY, R., MISHRA, A., VARMA, N., TANDON, JS., SAUX, M., CARPY, A. MINOR DITERPENES FROM COLEUS-FORSKOHLII. Phytochemistry, 1993, vol. 34, no. 6, p. 1577-1580. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature