Botanical species · safety record

Convallaria majalis

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 adverse-effect record for Convallaria majalis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Convallaria majalis L.

11Constituent measurements

1Safety records

7Cited sources

33Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 33 licensed products naming Convallaria majalis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Aerial parts
Fresh aerial part collected at flowering time
Fresh aerial parts
Fresh aerial parts collected at flowering time
Whole flowering plant
Whole flowering plant(s)
Whole plant in flower

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cardenolide glycosides	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Convallatoxin	Leaves	Solvent extraction	≤ 0.0389 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Convallatoxin	Leaves	Solvent extraction	≥ 0.0227 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Convallatoxin	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Periplorhamnoside	Leaves	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Steroidal glycosides	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Steroidal glycosides	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Convallatoxin	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Convallatoxin	Seed	Solvent extraction	—	Gaschromatography (GC)	No resolvable identifier
Convalloside	Seed	Solvent extraction	—	Gaschromatography (GC)	No resolvable identifier
Steroidal saponins	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Heart	Leaves	—	Dog (as animal)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kazarinov, N.A., Puchkova, E.I., Dzyuba, N.P. Quantitative determination of cardial glycosides of lily of the valley. Analysis of convallatoxin in the leaves of May (convallaria majalis), transcaucasian (convallaria transcaucasica utkin), and far-eastern (convallaria keiskei) lily of the valley. Pharmaceutical chemistry journal, 1969, vol. 3, no. 6, p. 347-349. DOI
Atkinson, Kathryn J., Fine, Deborah M., Evans, Tim J., Khan, Safdar. Suspected lily-of-the-valley (Convallaria majalis) toxicosis in a dog. Journal of veterinary emergency and critical care, 2008, vol. 18, no. 4, p. 399-403. DOI
Higano, Taro., Kuroda, Minpei., Sakagami, Hiroshi., Mimaki, Yoshihiro. Convallasaponin A, a new 5 beta-spirostanol triglycoside from the rhizomes of Convallaria majalis . Chemical & pharmaceutical bulletin, 2007, vol. 55, no. 2, p. 337-339. DOI
Matysik, G., Kowalski, J., Staszewska, M. Quantitative determination of convallatoxin from Herba Convallariae. Chromatographia, 1996, vol. 43(9/10), p. 559-562.
Nartowska, Jadwiga., Sommer, Ewa., Pastewka, Krzysztof., Sommer, Sylwester., Skopinska-Rozewska, Ewa. Anti-angiogenic activity of convallamaroside, the steroidal saponin isolated from the rhizomes and roots of Convallaria majalis L. . Acta poloniae pharmaceutica, 2004, vol. 61, no. 4, p. 279-82.
Harkiss, K.J., Linley, P.A., Mesbah, M.K.M. Analysis of cardenolides of Convallaria majalis by high pressure liquid chromatography. Journal of high resolution chromatography, 1981, vol. 4, no. 1, p. 37-38. DOI
Komissarenko, N. F. Convallatoxoloside, a new cardiac glycoside from seeds of Convallaria majalis. Doklady akademii nauk sssr, 1962, vol. 147, p. 625-7.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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