Botanical species · safety record

Coptis japonica

The EFSA Compendium of Botanicals holds 32 constituent measurements for Coptis japonica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Coptis japonica (Thunb.) Makino

32Constituent measurements

0Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	—	—	—	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	≥ 58.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	≤ 60.2 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	≥ 5.11 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Roots and other underground parts	Solvent extraction	≤ 6.91 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Berberine	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI
Columbamine	Roots and other underground parts	Solvent extraction	≥ 0.2 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Columbamine	Roots and other underground parts	Solvent extraction	≤ 0.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	≥ 10 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	≤ 13.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	≥ 0.77 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	≤ 1.63 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dimethyleneberberine	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI
Epiberberine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Isoquinoline alkaloids	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI
Jatrorrhizine	Roots and other underground parts	Solvent extraction	≥ 5.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Jatrorrhizine	Roots and other underground parts	Solvent extraction	≤ 7.2 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Jatrorrhizine	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	≥ 4.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Magnoflorine	Roots and other underground parts	Solvent extraction	≤ 5.8 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Magnoflorine	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI
Oxyberberine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	≥ 0.1 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	≤ 0.3 Milligram/gram	Capillary (Zone) Electrophoresis (CE or CZE)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	≥ 1.16 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Roots and other underground parts	Solvent extraction	≤ 1.69 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Palmatine	Unspecified	Solvent extraction	—	LC-TOF-MS	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Chintalwar, GJ., Gupta, S., Roja, G., Bapat, VA. Protoberberine alkaloids from callus and cell suspension cultures of Tinospora cordifolia . Pharmaceutical biology, 2003, vol. 41, no. 2, p. 81-86. DOI
LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . Phytochemical analysis, 1994, vol. 5, no. 5, p. 256-260. DOI
Chae, SH., Jeong, IH., Choi, DH., Oh, JW., Ahn, YJ. Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria . Journal of agricultural and food chemistry, 1999, vol. 47, no. 3, p. 934-938. DOI
Min, Yong Deuk., Yang, Min Cheol., Lee, Kyu Ha., Kim, Kyung Ran., Choi, Sang Un., Lee, Kang Ro. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino . Archives of pharmacal research, 2006, vol. 29, no. 9, p. 757-761. DOI
Hasada, Keiko., Yoshida, Takamitsu., Yamazaki, Takeshi., Sugimoto, Naoki., Nishimura, Tetsuji., Nagatsu, Akito., Mizukami, Hajime. Application of H-1-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma . Journal of natural medicines, 2011, vol. 65, no. 2, p. 262-267. DOI
Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, vol. 50, no. 3, p. 413-425. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature