Botanical species · safety record

Coptis trifolia

The EFSA Compendium of Botanicals holds 8 constituent measurements for Coptis trifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Coptis trifolia (L.) Salisb.

8Constituent measurements

0Safety records

4Cited sources

2Licensed products (Canada)

Also recorded as

Helleborus trifolius L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Coptis trifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Rhizome(s)
Root

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Berberine	Roots and other underground parts	Solvent extraction	3.8 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coptisine	Roots and other underground parts	Solvent extraction	3.44 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Epiberberine	Live plants	Solvent extraction	—	—	Resolve DOI
Groenlandicine	Live plants	Solvent extraction	—	—	Resolve DOI
Scopoletin	Live plants	Solvent extraction	—	—	Resolve DOI
Gallic acid	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier
Isoquinoline alkaloids	Unspecified	—	—	—	No resolvable identifier
Tannic acid	Roots and other underground parts	Solvent extraction	—	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kamath, Shreya., Skeels, Matthew., Pai, Aswini. Significant differences in alkaloid content of Coptis chinensis (Huanglian), from its related American species.. Chinese medicine, 2009, vol. 4, p. 17-17. DOI
Mollett, Charles E., Christensen, B. V. Coptis occidentalis Salisbury (family Ranunculaceae) western coptis, western goldthread. Journal of the American Pharmaceutical Association, None, p. 310-316.
Ji, Xiuhong., Zhang, Junzeng. Isoquinoline Alkaloids as Acetylcholinesterase Inhibitors from Coptis trifolia. PHARMACEUTICAL BIOLOGY, 2010, vol. 48, p. 30-31.
MIZUNO, M., KOJIMA, H., IINUMA, M., TANAKA, T., GOTO, K. COUMARIN DERIVATIVES IN COPTIS-TRIFOLIA. PHYTOCHEMISTRY, 1992, vol. 31, no. 2, p. 717-719. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature