Botanical species · safety record

Coscinium fenestratum

The EFSA Compendium of Botanicals holds 9 constituent measurements and 2 adverse-effect records for Coscinium fenestratum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Coscinium fenestratum (Goetgh.) Colebr.

9Constituent measurements

2Safety records

8Cited sources

2Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Coscinium fenestratum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Stem(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Berberine	Stem / stalk	Solvent extraction	≥ 2.67 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Berberine	Stem / stalk	Solvent extraction	≤ 3.37 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Bisbenzylisoquinoline alkaloids	Stem / stalk	Solvent extraction	—	LC-MS	Resolve DOI
Bisbenzylisoquinoline alkaloids	Bark	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Berberine	Stem / stalk	Solvent extraction	≥ 11.84 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Berberine	Stem / stalk	Solvent extraction	4.67 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Berberine	Stem / stalk	Solvent extraction	≤ 18.45 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Berberine	Stem / stalk	Solvent extraction	≤ 4.06 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Berberine	Stem / stalk	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Brain	Stem / stalk	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Brain	Stem / stalk	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Rojsanga, P., Gritsanapan, W. Variation of berberine content in Coscinium fenestratum stem in Thailand markets. Warasan Phesatchasat, 2005, p. 66-70.
Wattanathorn, Jintanaporn., Uabundit, Nongnut., Itarat, Wanchai., Mucimapura, Supaporn., Laopatarakasem, Pisamai., Sripanidkulchai, Bungorn. Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine. FOOD AND CHEMICAL TOXICOLOGY, 2006, vol. 44, no. 8, p. 1327-1333. DOI
Chitra, K., Sujatha, K., Polisetti, H., Karri, S., Umamaheswara Reddy, C. Standardization of Coscinium fenestratum with reference to berberine by high performance thin layer chromatography. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2011, vol. 2, no. 2, p. 226-229.
Rojsanga, Piyanuch., Gritsanapan, Wandee., Suntornsuk, Leena. Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry. MEDICAL PRINCIPLES AND PRACTICE, 2006, vol. 15, no. 5, p. 373-378. DOI
Babu, Ramesh., Thriveni, H. N., Vasudeva, R. Influence of drying methods and extraction procedures on the recovery of berberine content in Coscinium fenestratum. Journal of Natural Product and Plant Resources, 2012, p. 540-544.
Ldam, Arawwawala., Wan, Wickramaarachchi. Berberine content in Coscinium fenestratum grown in Sri Lanka. Research Reviews: Journal of Botanical Sciences, 2012, p. 1-4.
Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, vol. 50, no. 3, p. 413-425. DOI
PINHO, PMM., PINTO, MMM., KIJJOA, A., PHARADAI, K., DIAZ, JG., HERZ, W. PROTOBERBERINE ALKALOIDS FROM COSCINIUM-FENESTRATUM. PHYTOCHEMISTRY, 1992, vol. 31, no. 4, p. 1403-1407. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature