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Botanical species · safety record

Crescentia cujete

The EFSA Compendium of Botanicals holds 11 constituent measurements and 5 adverse-effect records for Crescentia cujete. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Crescentia cujete L.

11Constituent measurements
5Safety records
6Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Alkaloids2
  • Hydrogen cyanide (cyanides expressed as hydrogen cyanide)2
  • Oxalates2
  • Phytic acid2
  • Saponins2
  • Naphthoquinones1

Plant parts

  • Fruit unspecified9
  • Seed4
  • Live plants3

Preparations

  • Solvent extraction13
  • Fresh1

Effect types

  • Neurotoxicity3
  • Reproductive2

Target tissues

  • Neurologic: central nervous system3
  • Urogenital2

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
AlkaloidsFruit unspecifiedSolvent extraction≤ 0.74 PercentPhytochemical screeningNo resolvable identifier
AlkaloidsFruit unspecifiedSolvent extraction≥ 0.46 PercentPhytochemical screeningNo resolvable identifier
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)Fruit unspecifiedSolvent extraction≥ 0.23 PercentPhytochemical screeningNo resolvable identifier
Hydrogen cyanide (cyanides expressed as hydrogen cyanide)Fruit unspecifiedSolvent extraction≤ 0.28 PercentPhytochemical screeningNo resolvable identifier
NaphthoquinonesLive plantsSolvent extraction—Nuclear Magnetic Resonance (NMR)No resolvable identifier
OxalatesSeedSolvent extraction≥ 120 Milligram/kilogramUnspecifiedNo resolvable identifier
OxalatesSeedSolvent extraction≤ 155 Milligram/kilogramUnspecifiedNo resolvable identifier
Phytic acidSeedSolvent extraction≥ 220 Milligram/kilogramUnspecifiedNo resolvable identifier
Phytic acidSeedSolvent extraction≤ 330 Milligram/kilogramUnspecifiedNo resolvable identifier
SaponinsFruit unspecifiedSolvent extraction≥ 0.34 PercentPhytochemical screeningNo resolvable identifier
SaponinsFruit unspecifiedSolvent extraction≤ 0.7 PercentPhytochemical screeningNo resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
NeurotoxicityNeurologic: central nervous systemLive plantsSolvent extractionHouse mouse (as animal)Short-term toxicityNo resolvable identifier
NeurotoxicityNeurologic: central nervous systemFruit unspecifiedFreshHouse mouse (as animal)Short-term toxicityNo resolvable identifier
NeurotoxicityNeurologic: central nervous systemLive plantsSolvent extractionHouse mouse (as animal)Short-term toxicityNo resolvable identifier
ReproductiveUrogenitalFruit unspecified—Goat (as animal)Reproduction toxicityNo resolvable identifier
ReproductiveUrogenitalFruit unspecified—Goat (as animal)Reproduction toxicityNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Aderibigbe, A. O., Olufunmilayo, T., Agboola, O., I. CNS depressant properties of the crude extract of Crescentia cujete in mice . Planta medica, 2013, vol. 79, no. 13, p. 1161-1161.
  2. Assis, Tales S., Medeiros, Rosane M. T., de Araujo, Jose Allan S., Dantas, Antonio F. M., Riet-Correa, Franklin. Plant poisonings in ruminants and equidae in the Sertao of Paraiba, Brazil. . Pesquisa veterinaria brasileira, 2009, vol. 29, no. 11, p. 919-924.
  3. Krishna, Vivek., Khandelwal, Poonam., Koolwal, Neetu., Sharma, M. C., Singh, Pahup. Quinonoid molecular diversity in Bignoniaceae and its taxonomic significance . Journal of the indian chemical society, 2012, vol. 89, no. 8, p. 1019-1024.
  4. Ogbuagu, Marc Nwosu. The Nutritive and Anti-Nutritive Compositions of Calabash (Crescentia cujete) Fruit Pulp. Journal of Animal and Veterinary Advances, 2008, vol. 7, no. 9, p. 1069-1072.
  5. Hetzel, C E., Gunatilaka, A A., Glass, T E., Kingston, D G., Hoffmann, G., Johnson, R K. Bioactive furanonaphthoquinones from Crescentia cujete.. Journal of natural products, 1993, vol. 56, no. 9, p. 1500-5.
  6. Oyeleke, G. O., Sulaiman, W. K., Adebayo, G. O., Ogunwale, A. O. Effect of dehulling on the nutritive and anti-nutritive components of calabash (Crescentia cujete L.) seed. International journal of chemistry (calcutta, india), 2011, p. 219-224.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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In its own terms

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How the living traditions approach preparation, use and context.