Botanical species · safety record

Crotalaria retusa

The EFSA Compendium of Botanicals holds 2 constituent measurements, 9 adverse-effect records and 1 genotoxicity assay for Crotalaria retusa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Crotalaria retusa L.

2Constituent measurements

10Safety records

4Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Monocrotaline	Seed	—	6.84 Percent	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Monocrotaline	Seed	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Seed	—	Sheep (as animal)	Acute toxicity	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Gallus gallus (chicken) (as animal)	Chronic/long term toxicity	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Sheep (as animal)	Chronic/long term toxicity	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Pig (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Seed	—	Pig (as animal)	Short-term toxicity	Resolve DOI
Nephrotoxicity	Urogenital: kidneys	Seed	—	Gallus gallus (chicken) (as animal)	Chronic/long term toxicity	Resolve DOI
Neurotoxicity	Neurologic: central nervous system	Seed	—	Cattle (as animal)	Case report	Resolve DOI
Pulmonary and cardiac	Lung	Seed	—	Pig (as animal)	Short-term toxicity	Resolve DOI
Teratogenic	Muscle, skeletal	Seed	—	Pig (as animal)	Reproduction toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

HOOPER, PT., SCANLAN, WA. CROTALARIA-RETUSA POISONING OF PIGS AND POULTRY. AUSTRALIAN VETERINARY JOURNAL, 1977, vol. 53, no. 3, p. 109-114. DOI
Silva-Neto, J. P., Barreto, R. A., Pitanga, B. P. S., Souza, C. S., Silva, V. D., Silva, A. R., Velozo, E. S., Cunha, S. D., Batatinha, M. J. M., Tardy, M., Ribeiro, C. S. O., Costa, M. F. D., El-Bacha, R. S., Costa, S. L. Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells. TOXICON, 2010, vol. 55, no. 1, p. 105-117. DOI
Anjos, Bruno Leite., Nobre, Veronica M. T., Dantas, Antonio F. M., Medeiros, Rosane M. T., Oliveira Neto, Temistocles S., Molyneux, Russell J., Riet-Correa, Franklin. Poisoning of sheep by seeds of Crotalaria retusa: Acquired resistance by continuous administration of low doses. TOXICON, 2010, vol. 55, no. 1, p. 28-32. DOI
Seara Pitanga, Bruno Penas., Nascimento, Ravena P., Silva, Victor Diogenes A., Costa, Silvia L. The role of astrocytes in metabolism and neurotoxicity of the pyrrolizidine alkaloid monocrotaline, the main toxin of Crotalaria retusa. FRONTIERS IN PHARMACOLOGY, 2012, vol. 3. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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