Botanical species · safety record

Crotalaria spectabilis

The EFSA Compendium of Botanicals holds 9 constituent measurements and 12 adverse-effect records for Crotalaria spectabilis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Crotalaria spectabilis Roth

9Constituent measurements

12Safety records

12Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Monocrotaline	Seed	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Monocrotaline	Seed	—	3.5 Percent	Unspecified	Resolve DOI
Pyrrolizidine alkaloids	Unspecified	—	0.6 Milligram/gram	GC-MS	Resolve DOI
Tannins	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Monocrotaline	Leaves	—	≤ 0.88 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Monocrotaline	Seed	—	≤ 4.7 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Monocrotaline	Seed	—	≥ 2.75 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Monocrotaline	Leaves	—	≥ 0.01 Percent	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hemopoietic	Liver	Unspecified	—	Gallus gallus (chicken) (as animal)	Other	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Goat (as animal)	Other	Resolve DOI
Hepatotoxicity	Liver	Seed	—	Goat (as animal)	Subchronic	Resolve DOI
Reproductive	Liver	Seed	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Digestive	Lung	—	—	Cattle (as animal)	Case report	No resolvable identifier
Hepatotoxicity	Liver	Seed	—	Pig (as animal)	Short-term toxicity	No resolvable identifier
Hepatotoxicity	Liver	Seed	—	Pig (as animal)	Short-term toxicity	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	Seed	Powder	Rat (as animal)	Subchronic	No resolvable identifier
Nephrotoxicity	Urogenital: kidneys	Seed	Powder	Rat (as animal)	Subchronic	No resolvable identifier
Nephrotoxicity	Liver	Seed	—	Gallus gallus (chicken) (as animal)	Short-term toxicity	No resolvable identifier
Nephrotoxicity	Liver	Seed	—	Gallus gallus (chicken) (as animal)	Short-term toxicity	No resolvable identifier
Not stated	Liver	Seed	—	Pig (as animal)	Short-term toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Carstens, Laurine A., Allen, James Richard. Arterial degeneration and glomerular hyalinization in the kidney of monocrotaline-intoxicated rats. American journal of pathology, 1970, vol. 60, no. 1, p. 75-92.
ALLEN, JR., CARSTENS, LA., NORBACK, DH. ULTRASTRUCTURAL AND BIOCHEMICAL CHANGES IN LIVER OF MONOCROTALINE INTOXICATED CHICKENS . Toxicology and applied pharmacology, 1970, vol. 16, no. 3, p. 800-&. DOI
Thomas, E. W., Neal, W. M., Ahmann, C. F. The toxicity of Crotalaria spectabilis Roth to livestock and poultry. Journal of the american society of agronomy, 1935, vol. 27, p. 499-500.
Medeiros, RMT., Gorniak, SL., Guerra, JL. Fetotoxicity and reproductive effects of monocrotaline in pregnant rats. Journal of ethnopharmacology, 2000, vol. 69, no. 2, p. 181-188. DOI
Johnson, A. Earl., Molyneux, Russell J., Merrill, Glory B. Chemistry of toxic range plants. Variation in pyrrolizidine alkaloid content of Senecio, Amsinckia, and Crotalaria species. Journal of agricultural and food chemistry, 1985, vol. 33, no. 1, p. 50-5.
Allen, J.R., Carstens, L.A. Pulmonary vascular occlusions initiated by endothelial lysis in monocrotaline-intoxicated rats. Experimental and molecular pathology, 1970, vol. 13, no. 2, p. 159-171. DOI
Pires, Ana Paula C., Oliveira, Mariana C., Braga, Karina M., Malafaia, Pedro., Barros, Janne P. N., Tokarnia, Carlos H., Brito, Marilene F. Study about the sensitivity of goats to the toxicity of crotalarias poisonous for cattle aiming their use for prophylactic measures . Pesquisa veterinaria brasileira, 2015, vol. 35, no. 6, p. 501-512. DOI
Hatayde, MR., Alessi, AC., Berchieri, A., Cafe, MB., Curtarelli, SM. Poisoning of broilers by Crotalaria spectabilis .2. Experimental study on birds during the final phase of growth . Arquivo brasileiro de medicina veterinaria e zootecnia, 1997, vol. 49, no. 2, p. 239-249.
Ubiali, Daniel G., Boabaid, Fabiana M., Borges, Nayani A., Caldeira, Flavio H. B., Lodi, Luciano R., Pescador, Caroline A., Souza, Marcos A., Colodel, Edson M. Acute poisoning with Crotalaria spectabilis (Leg. Papilionoideae) seeds in pigs . Pesquisa veterinaria brasileira, 2011, vol. 31, no. 4, p. 313-318.
Tinker, R.B., Lauter, W.M. Constituents of Crotalaria spectabilis roth. Economic botany, 1956, vol. 10, no. 3, p. 254-257. DOI
Souza, AC., Hatayde, MR., Bechara, GH. Pathological aspects of poisoning by Crotalaria spectabilis (Fabaceae) seeds in swine. . Pesquisa veterinaria brasileira, 1997, vol. 17, no. 1, p. 12-18.
Fletcher, Mary T., Mckenzie, Ross A., Blaney, Barry J., Reichmann, Keith G. Pyrrolizidine Alkaloids in Crotalaria Taxa from Northern Australia: Risk to Grazing Livestock . Journal of agricultural and food chemistry, 2009, vol. 57, no. 1, p. 311-319. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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