Botanical species · safety record

Croton flavens

The EFSA Compendium of Botanicals holds 13 constituent measurements and 1 adverse-effect record for Croton flavens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Croton flavens L.

13Constituent measurements

1Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Amuronine	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coreximine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Flavinantine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Norsinoacutine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Phenanthrenes	Leaves	Solvent extraction	—	HPLC-DAD	Resolve DOI
Saludimerine a	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Scoulerine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Sebiferine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Sinoacutine	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Flavinantine	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Flavinine	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Norsinoacutine	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Sinoacutine	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	Digestive: esophagus	Roots and other underground parts	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Weber, J., Hecker, E. Cocarcinogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curacao. Experientia, 1978, p. 679-682.
Eisenreich, WJ., Hofner, G., Bracher, F. Alkaloids from Croton flavens L. and their affinities to GABA-receptors. NATURAL PRODUCT RESEARCH, 2003, vol. 17, no. 6, p. 437-440. DOI
Eisenreich, WJ., Bracher, F. Crotoflavol, a new phenanthrene from Croton flavens. NATURAL PRODUCT LETTERS, 2001, vol. 15, no. 2, p. 147-150. DOI
Stuart, Kenneth L., Chambers, Clinton., Byfield, D. Morphinandienone alkaloids from Croton flavens. Journal of the Chemical Society [Section] C: Organic, 1969, p. 1681-1684.
Charris, J., Dominguez, J., de la Rosa, C., Caro, C. (-)-amuronine from the leaves of Croton flavens L. (Euphorbiaceae). BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2000, vol. 28, no. 8, p. 795-797. DOI
Bracher, F., Eisenreich, WJ., Muhlbacher, J., Dreyer, M., Bringmann, G. Saludimerines A and B, novel-type dimeric alkaloids with stereogenic centers and configurationally semistable biaryl axes. JOURNAL OF ORGANIC CHEMISTRY, 2004, vol. 69, no. 25, p. 8602-8608. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature