Botanical species · safety record

Daphne genkwa

The EFSA Compendium of Botanicals holds 16 constituent measurements, 7 adverse-effect records and 1 genotoxicity assay for Daphne genkwa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Daphne genkwa Siebold & Zucc.

16Constituent measurements

8Safety records

10Cited sources

4Licensed products (Canada)

Also recorded as

Wikstroemia genkwa (Siebold & Zucc.) Domke

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Daphne genkwa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Flower buds
New material

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Benzofurans	Flower	Essential oil	2.7 Percent	GC-FID	Resolve DOI
Daphnane diterpenes	Bud	Solvent extraction	—	LC-MS	Resolve DOI
Daphnane diterpenes	Bud	—	—	Unspecified	Resolve DOI
Daphnane diterpenes	Bud	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Elemicin	Flower	Essential oil	4.5 Percent	GC-FID	Resolve DOI
Furfural	Flower	Essential oil	2.8 Percent	GC-FID	Resolve DOI
Lignans	Bud	Powder	—	LC-MS	Resolve DOI
Methyleugenol	Flower	Essential oil	4.6 Percent	GC-FID	Resolve DOI
Yuanhuacine	Bud	Solvent extraction	7.4 Milligram/gram	LC-MS	Resolve DOI
Yuanhuadine	Bud	Solvent extraction	10.7 Milligram/gram	LC-MS	Resolve DOI
Yuanhuafin	Bud	Solvent extraction	1.97 Milligram/gram	LC-MS	Resolve DOI
Yuanhuapine	Bud	—	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Yuanhuapine	Bud	Solvent extraction	1.31 Milligram/gram	LC-MS	Resolve DOI
Yuanhuatine	Bud	Solvent extraction	1.04 Milligram/gram	LC-MS	Resolve DOI
Coumarins	Stem / stalk	Solvent extraction	—	Unspecified	No resolvable identifier
Coumarins	Roots and other underground parts	—	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Bud	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Hepatotoxicity	Liver	Bud	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Reproductive	Urogenital	Bud	Solvent extraction	—	In vitro	Resolve DOI
Systemic	Respiratory	Bud	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	—	Bud	—	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	—	Bud	—	Rat (as animal)	Acute toxicity	Resolve DOI
Systemic	—	—	—	House mouse (as animal)	Acute toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Zhang, Yuanyuan., Zhang, Ruowen., Yuan, Yang., Geng, Lulu., Zhao, Xu., Meng, Xia., Zhuang, Hefei., Bi, Kaishun., Chen, Xiaohui. Simultaneous determination of eight active components in chloroform extracts from raw and vinegar-processed Genkwa flos using HPLC-MS and identification of the hepatotoxic ingredients with an HL-7702 cell . Analytical methods, 2014, vol. 6, no. 17, p. 7022-7029. DOI
Yun, Jun-Won., Kim, Seung-Hyun., Kim, Yun-Soon., You, Ji-Ran., Kwon, Euna., Jang, Ja-June., Park, In Ae., Kim, Hee Chan., Kim, Hyeon Hoe., Che, Jeong-Hwan., Kang, Byeong-Cheol. Evaluation of subchronic (13 week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos . Regulatory toxicology and pharmacology, 2015, vol. 72, no. 2, p. 386-393. DOI
Chen, Yan-Yan., Guo, Jian-Ming., Qian, Ye-Fei., Guo, Sheng., Ma, Chun-Hua., Duan, Jin-Ao. Toxicity of daphnane-type diterpenoids from Genkwa Flos and their pharmacokinetic profile in rat . Phytomedicine, 2013, vol. 21, no. 1, p. 82-89. DOI
Chen, Yanyan., Guo, Jianming., Tang, Yuping., Wu, Liang., Tao, Weiwei., Qian, Yefei., Duan, Jin-ao. Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry . Journal of pharmaceutical and biomedical analysis, 2015, vol. 112, p. 60-69. DOI
Ueyama, Y., Hashimoto, S., Nii, H., Furukawa, K. The chemical composition of the essential oil of Daphne genkwa sieb. et zucc.. Journal of essential oil research, 1990, vol. 2, no. 5, p. 247-250. DOI
Li, Lin-Yan., Cao, Fen-Fang., Su, Zhi-Jian., Zhang, Qi-Hao., Dai, Xiao-Yong., Xiao, Xue., Huang, Ya-Dong., Zheng, Qing., Xu, Hua. Assessment of the embryotoxicity of four Chinese herbal extracts using the embryonic stem cell test . Molecular medicine reports, 2015, vol. 12, no. 2, p. 2348-2354. DOI
Kang, Ho-Bum., Lee, Ha-Reum., Jee, Da Jung., Shin, Su-Hyun., Nah, Seong-Su., Yoon, Sun Young., Kim, Jae Wha. PRDM1, a Tumor-Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells . Journal of cellular biochemistry, 2016, vol. 117, no. 1, p. 172-179. DOI
Zhan, ZJ., Fan, CQ., Ding, J., Yue, HM. Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa . Bioorganic & medicinal chemistry, 2005, vol. 13, no. 3, p. 645-655. DOI
He, Lei., Shi, Qi-rong., Liu, Run-hui., Xu, Xi-ke., Shen, Yun-heng., Li, Hui-liang., Zhang, Wei-dong. Coumarins from the branches of Daphne genkwa. Yaoxue shijian zazhi, 2008, vol. 26, no. 6, p. 441-443.
Shi, Feng., Zheng, Wei-fa. Phenolic constituents from the roots of Daphne genkwa and their immunomodulatory activity. Xuzhou shifan daxue xuebao, ziran kexueban, 2004, vol. 22, no. 4, p. 34-40.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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