Botanical species · safety record

Daphne gnidium

The EFSA Compendium of Botanicals holds 6 constituent measurements and 1 genotoxicity assay for Daphne gnidium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Daphne gnidium L.

6Constituent measurements

1Safety records

5Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Coumarins	Aerial part of plants	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Coumarins	Leaves	Solvent extraction	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Daphnetoxin	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Coumarins	Leaves	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	SOS/umu test	Escherichia coli (as organism)	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Chaabane Fadwa., Boubaker Jihed., Loussaif Amira., Neffati Aicha., Kilani-Jaziri Somaya., Ghedira Kamel., Chekir-Ghedira Leila. Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts. Bmc complementary and alternative medicine, 2012, vol. 12, p. 153.
Nowik, W. HPLC-PDA characterisation of Daphne gnidium L. (Thymemeacea) dyeing extracts using two different C-18 stationary phases . Journal of separation science, 2005, vol. 28, no. 13, p. 1595-1600. DOI
Deiana, M., Rosa, A., Casu, V., Cottiglia, L., Bonsignore, L., Dessi, MA. Chemical composition and antioxidant activity of extracts from Daphne gnidium L. . Journal of the american oil chemists society, 2003, vol. 80, no. 1, p. 65-70. DOI
Cottiglia, F., Bonsignore, L., Loy, G., Garau, D., Floris, C., Casu, M. Structure elucidation and antibacterial activity of a new coumarinolignoid from Daphne gnidium L. . Magnetic resonance in chemistry, 2002, vol. 40, no. 8, p. 551-553. DOI
Peixoto, F., Carvalho, MJM., Almeida, J., Matos, PAC. Daphnetoxin interacts with mitochondrial oxidative phosphorylation and induces membrane permeability transition in rat liver . Planta medica, 2004, vol. 70, no. 11, p. 1064-1068. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature