Botanical species · safety record

Daphne mezereum

The EFSA Compendium of Botanicals holds 11 constituent measurements and 3 adverse-effect records for Daphne mezereum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Daphne mezereum L.

11Constituent measurements

3Safety records

8Cited sources

10Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 10 licensed products naming Daphne mezereum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Bark
Fresh bark from the branches collected prior to flowering
Parties aériennes fraîches récoltées au moment de la floraison

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Coumarin glycosides	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Diterpene esters	Bark	Solvent extraction	—	HPLC-MS/MS	Resolve DOI
Diterpene esters	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Lignans	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Mezerein	Fruit unspecified	—	—	HPLC-MS/MS	Resolve DOI
Daphnetoxin	Bark	Solvent extraction	0.02 Percent	—	No resolvable identifier
Daphnetoxin	Seed	—	0.02 Percent	—	No resolvable identifier
Daphnin	Bark	—	—	—	No resolvable identifier
Daphnin	Flower	—	—	—	No resolvable identifier
Daphnoretin	Fruit unspecified	—	—	—	No resolvable identifier
Mezerein	Seed	—	0.1 Percent	—	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Stomach	Fruit unspecified	—	Pig (as animal)	Case report	No resolvable identifier
Not reported	—	Bark	Raw, no heat treatment	Human (as organism)	Case report	No resolvable identifier
Pulmonary and cardiac	—	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Goerick, C., Melzig, M. F. Gniditrin is the main diterpenoid constituent in the bark of Daphne mezereum L. . Pharmazie, 2013, vol. 68, no. 7, p. 640-642. DOI
KREHER, B., NESZMELYI, A., WAGNER, H. TRIUMBELLIN, A TRICOUMARIN RHAMNOPYRANOSIDE FROM DAPHNE-MEZEREUM. Phytochemistry, 1990, vol. 29, no. 11, p. 3633-3637. DOI
Stout, George H., Balkenhol, Wayne J., Poling, Mitchell., Hickernell, Gary L. Isolation and structure of daphnetoxin, the poisonous principle of Daphne species. Journal of the american chemical society, 1970, vol. 92, no. 4, p. 1070-1.
Ronlan, Alvin., Wickberg, Borje. Structure of mezerein, a major toxic principle of Daphne mezereum. Tetrahedron letters, 1970, vol. (49), p. 4261-4.
Tschesche, Rudolf., Schacht, Ulrich., Legler, Guenter. Daphnoretin, a naturally occurring derivative of 3,7'-dicoumaryl ether. Annalen der chemie, justus liebigs, 1963, vol. 662, p. 113-25.
Duncanson, Graham R. Poisons and Causes of Sudden Death. Veterinary treatment of pigs, 2013, p. 131-140.
Hecker, E. Cocarcinogens from Euphorbiaceae and Thymeleaceae. Pharmacogn. phytochem., int. congr., 1st, 1971, p. 147-65.
PERNTHANER, A., LANGER, T. POISONING WITH DAPHNE-MEZEREUM IN CATTLE. Wiener tierarztliche monatsschrift, 1993, vol. 80, no. 5, p. 138-142.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature