Botanical species · safety record
Datura innoxia
The EFSA Compendium of Botanicals holds 21 constituent measurements and 2 adverse-effect records for Datura innoxia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.
Accepted name in source: Datura innoxia Mill.
Also recorded as
Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.
Regulatory presence
No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.
What the records describe
Constituents measured
- Atropine9
- Scopolamine9
- Cardiac glycosides1
- Saponins1
- Tropane alkaloids1
Plant parts
- Leaves7
- Live plants7
- Flower6
- Stem2
- stalk2
- Roots and other underground parts1
Preparations
- Solvent extraction15
- Thermal treatment (heating for preservation)3
Effect types
- Neurotoxicity2
Target tissues
- Neurologic: central nervous system2
Recorded constituents
What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.
| Substance | Plant part | Preparation | Concentration | Analytical method | Source |
|---|---|---|---|---|---|
| Atropine | Live plants | Solvent extraction | ≤ 1330 Microgram/gram | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Atropine | Live plants | Solvent extraction | ≥ 60 Microgram/gram | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Scopolamine | Live plants | Solvent extraction | ≤ 4000 Microgram/gram | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Scopolamine | Live plants | Solvent extraction | ≥ 60 Microgram/gram | Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) | Resolve DOI |
| Atropine | Stem / stalk | Solvent extraction | 0.4 Milligram/gram | LC-MS | No resolvable identifier |
| Atropine | Leaves | Thermal treatment (heating for preservation) | 0.8 Microgram/gram | GC-MS | No resolvable identifier |
| Atropine | Flower | Solvent extraction | 0.03 Milligram/gram | LC-MS | No resolvable identifier |
| Atropine | Flower | — | ≥ 1.79 Microgram/millilitre | LC-MS | No resolvable identifier |
| Atropine | Flower | — | ≤ 37 Microgram/millilitre | LC-MS | No resolvable identifier |
| Atropine | Leaves | Solvent extraction | ≥ 0.02 Milligram/gram | LC-MS | No resolvable identifier |
| Atropine | Leaves | Solvent extraction | ≤ 0.06 Milligram/gram | LC-MS | No resolvable identifier |
| Cardiac glycosides | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
| Saponins | Live plants | Solvent extraction | — | Phytochemical screening | No resolvable identifier |
| Scopolamine | Flower | Solvent extraction | 3.94 Milligram/gram | LC-MS | No resolvable identifier |
| Scopolamine | Stem / stalk | Solvent extraction | 1.95 Milligram/gram | LC-MS | No resolvable identifier |
| Scopolamine | Leaves | Thermal treatment (heating for preservation) | 1.2 Microgram/gram | GC-MS | No resolvable identifier |
| Scopolamine | Leaves | Solvent extraction | ≤ 4.53 Milligram/gram | LC-MS | No resolvable identifier |
| Scopolamine | Leaves | Solvent extraction | ≥ 0.94 Milligram/gram | LC-MS | No resolvable identifier |
| Scopolamine | Flower | — | ≤ 400.04 Microgram/millilitre | LC-MS | No resolvable identifier |
| Scopolamine | Flower | — | ≥ 57.8 Microgram/millilitre | LC-MS | No resolvable identifier |
| Tropane alkaloids | Live plants | Solvent extraction | — | GC-MS | No resolvable identifier |
Recorded adverse effects
Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.
| Effect | Target tissue | Plant part | Preparation | Test organism | Test type | Source |
|---|---|---|---|---|---|---|
| Neurotoxicity | Neurologic: central nervous system | Roots and other underground parts | — | Human (as organism) | Case report | Resolve DOI |
| Neurotoxicity | Neurologic: central nervous system | Leaves | Thermal treatment (heating for preservation) | Human (as organism) | Case report | No resolvable identifier |
Cited sources
The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.
- Oniszczuk, A., Waksmundzka-Hajnos, M., Gadzikowska, M., Podgorski, R., Oniszczuk, T. Influence of Sample Preparation Methods on the Quantitation of Selected Tropane Alkaloids from Herb of Datura innoxia Mill. by HPTLC . Acta chromatographica, 2013, vol. 25, no. 3, p. 545-554. DOI
- Jakabova, Silvia., Vincze, Lajos., Farkas, Agnes., Kilar, Ferenc., Boros, Borbala., Felinger, Attila. Determination of tropane alkaloids atropine and scopolamine by liquid chromatography-mass spectrometry in plant organs of Datura species. Journal of chromatography a, 2012, vol. 1232, p. 295-301.
- Ayuba, V. O., Ojobe, T. O., Ayuba, S. A. Phytochemical and proximate composition of Datura innoxia leaf, seed, stem, pod and root. Journal of medicinal plants research, 2011, vol. 5, no. 14, p. 2952-2955.
- Papoutsis, Ioannis., Nikolaou, Panagiota., Athanaselis, Sotirios., Stefanidou, Maria., Pistos, Constantinos., Spiliopoulou, Chara., Maravelias, Constantinos. Mass intoxication with Datura innoxia-case series and confirmation by analytical toxicology. Clinical toxicology, 2010, vol. 48, no. 2, p. 143-145.
- HANNA, JP., SCHMIDLEY, JW., BRASELTON, WE. DATURA DELIRIUM. Clinical neuropharmacology, 1992, vol. 15, no. 2, p. 109-113. DOI
- Boros, Borbala., Farkas, Agnes., Jakabova, Silvia., Bacskay, Ivett., Kilar, Ferenc., Felinger, Attila. LC-MS Quantitative Determination of Atropine and Scopolamine in the Floral Nectar of Datura Species. Chromatographia, 2010, vol. 71(Suppl.), p. S43-S49.
- El Bazaoui, Ahmed., Bellimam, My Ahmed., Soulaymani, Abdelmajid. Tropane alkaloids of Datura innoxia from Morocco. Zeitschrift fuer naturforschung, c: journal of biosciences, 2012, vol. 67(1/2), p. 8-14.
Boundary
A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.
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