Botanical species · safety record

Datura metel

The EFSA Compendium of Botanicals holds 36 constituent measurements and 7 adverse-effect records for Datura metel. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Datura metel L.

36Constituent measurements

7Safety records

15Cited sources

3Licensed products (Canada)

Also recorded as

Datura alba F.Muell.
Datura alba Rumph. ex Nees

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 3 licensed products naming Datura metel as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Flower
Leaf extract

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Atropine	Fruit unspecified	Solvent extraction	≥ 0.71 Milligram/gram	LC-MS	Resolve DOI
Atropine	Fruit unspecified	Solvent extraction	≤ 1.37 Milligram/gram	LC-MS	Resolve DOI
Atropine	Leaves	Solvent extraction	≥ 0.13 Milligram/gram	LC-MS	Resolve DOI
Atropine	Leaves	Solvent extraction	≤ 1.21 Milligram/gram	LC-MS	Resolve DOI
Atropine	Stem / stalk	Solvent extraction	≥ 0.83 Milligram/gram	LC-MS	Resolve DOI
Atropine	Stem / stalk	Solvent extraction	≤ 1.33 Milligram/gram	LC-MS	Resolve DOI
Hyoscyamine	Flower	—	≥ 0.045 Percent	Unspecified	Resolve DOI
Hyoscyamine	Flower	—	≤ 0.0645 Percent	Unspecified	Resolve DOI
Scopolamine	Flower	—	≤ 0.365 Percent	Unspecified	Resolve DOI
Scopolamine	Stem / stalk	Solvent extraction	≥ 0.01 Milligram/gram	LC-MS	Resolve DOI
Scopolamine	Stem / stalk	Solvent extraction	≤ 3.42 Milligram/gram	LC-MS	Resolve DOI
Scopolamine	Flower	—	≥ 0.255 Percent	Unspecified	Resolve DOI
Scopolamine	Leaves	Solvent extraction	≤ 0.28 Milligram/gram	LC-MS	Resolve DOI
Scopolamine	Leaves	Solvent extraction	≥ 0.01 Milligram/gram	LC-MS	Resolve DOI
Scopolamine	Fruit unspecified	Solvent extraction	≥ 0.45 Milligram/gram	LC-MS	Resolve DOI
Scopolamine	Fruit unspecified	Solvent extraction	≤ 3.44 Milligram/gram	LC-MS	Resolve DOI
Steroidal glycosides	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tannins	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Tropane alkaloids	Flower	—	≤ 0.43 Percent	Unspecified	Resolve DOI
Tropane alkaloids	Flower	—	≥ 0.3 Percent	Unspecified	Resolve DOI
Alkaloids	Leaves	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Alkaloids	Seed	Solvent extraction	0.526 Percent	GC-MS	No resolvable identifier
Anthraquinones	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Apohyoscine (aposcopolamine)	Seed	Solvent extraction	1.72 Percent	HPLC with standard detection methods	No resolvable identifier
Atropine	Flower	Solvent extraction	4.11 Microgram/millilitre	LC-MS	No resolvable identifier
Atropine	Seed	Solvent extraction	0.132 Percent	HPLC with standard detection methods	No resolvable identifier
Cardiac glycosides	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Hyoscyamine	Seed	Solvent extraction	3.71 Percent	GC-MS	No resolvable identifier
Hyoscyamine	Leaves	—	≥ 0.12 Percent	Unspecified	No resolvable identifier
Hyoscyamine	Leaves	—	≤ 0.26 Percent	Unspecified	No resolvable identifier
Saponins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Scopolamine	Seed	Solvent extraction	3.2 Percent	GC-MS	No resolvable identifier
Scopolamine	Flower	Solvent extraction	128.22 Microgram/millilitre	LC-MS	No resolvable identifier
Tannins	Leaves	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tropane alkaloids	Roots and other underground parts	—	—	Chromatographic tests	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Liver	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Neurotoxicity	Liver	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Teratogenic	Brain	Leaves	Solvent extraction	Rat (as animal)	Reproduction toxicity	Resolve DOI
Musclo-skeletal	Heart	Unspecified	—	Human (as organism)	Case report	No resolvable identifier
Other toxicities	—	Leaves	Solvent extraction	Nile tilapia	Subchronic	No resolvable identifier
Other toxicities	—	Leaves	Solvent extraction	Nile tilapia	Subchronic	No resolvable identifier
Reproductive	—	Roots and other underground parts	Raw, no heat treatment	—	Reproduction toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ashraf, M., Ayub, M., Sajjad, T., Elahi, N., Ali, I., Ahmed, Z. Replacement of rotenone by locally grown herbal extracts. International journal of agriculture and biology, 2010, vol. 12, no. 1, p. 77-80.
Das, B., Choudhury, M.D., Talukdar, A.D. A few traditional medicinal plants used as antifertility agents by ethnic people of Tripura, India. International journal of pharmacy and pharmaceutical sciences, 2014, vol. 6, no. 3, p. 47-53.
Chan, T.Y.K. Herbal medicines induced anticholinergic poisoning in Hong Kong. Toxins, 2016, vol. 8, no. 3. DOI
Ishola, Azeez Olakunle., Adeniyi, Philip Adeyemi. Retarded hippocampal development following prenatal exposure to ethanolic leaves extract of Datura metel in wistar rats. . Nigerian medical journal : journal of the nigeria medical association, 2013, vol. 54, no. 6, p. 411-4. DOI
Fu, Yonghong., Si, Zhihong., Li, Pumin., Li, Minghui., Zhao, He., Jiang, Lei., Xing, Yuexiao., Hong, Wei., Ruan, Lingyu., Wang, Jun-Song. Acute psychoactive and toxic effects of D-metel on mice explained by H-1 NMR based metabolomics approach . Metabolic brain disease, 2017, vol. 32, no. 4, p. 1295-1309. DOI
Patel, Yogesh., Bhat, Savitha D., Acharya, Rabinarayan., Ashok, B. K., Shukla, V. J. Role of Shodhana on analytical parameters of Datura innoxia Mill and Datura metel Linn seeds. International journal of research in ayurveda & pharmacy, 2010, vol. 1, no. 2, p. 249-254.
Wahid, M. A., Samiullah. Standardization of active principles of indigenous pharmacopoeial drugs found in West Pakistan. Pakistan journal of scientific and industrial research, 1960, vol. 3, p. 228-30.
Jakabova, Silvia., Vincze, Lajos., Farkas, Agnes., Kilar, Ferenc., Boros, Borbala., Felinger, Attila. Determination of tropane alkaloids atropine and scopolamine by liquid chromatography-mass spectrometry in plant organs of Datura species . Journal of chromatography a, 2012, vol. 1232, p. 295-301. DOI
Boros, Borbala., Farkas, Agnes., Jakabova, Silvia., Bacskay, Ivett., Kilar, Ferenc., Felinger, Attila. LC-MS Quantitative Determination of Atropine and Scopolamine in the Floral Nectar of Datura Species. Chromatographia, 2010, vol. 71(Suppl.), p. S43-S49.
Karunakar, T., Shankaraiah, A., Parvathi, D., Ugandhar, T. Investigation of the phytochemical analysis and biological activities in Datura metel. Linn. European journal of biomedical and pharmaceutical sciences, 2016, vol. 3, no. 5, p. 329-334.
Anwar, K., Ghani, A. Alkaloids of the roots of Datura metel var fastuosa grown in Bangladesh. Bangladesh pharmaceutical journal, 1973, vol. 2, no. 2, p. 25-7.
Kuganathan, Navaratnarajah., Ganeshalingam, Sashikesh. Chemical Analysis of Datura Metel Leaves and Investigation of the Acute Toxicity on Grasshoppers and Red Ants . E-journal of chemistry, 2011, vol. 8, no. 1, p. 107-112.
Babalola, S.A., Suleiman, M.M., Hassan, A.Z., Adawa, D. Evaluation of the crude methanolic seed extract of Datura metel L. as a potential oral anaesthetic in dogs. Global journal of pharmacology, 2014, vol. 8, no. 2, p. 154-159. DOI
Chhatre, Vibhavari., Nesari, Tanuja., Somani, Gauresh., Chaudhari, Rahul., Sathaye, Sadhana. Studies on the process of detoxification and safety evaluation of shodhit and ashodhit Datura metel seeds for the use in Ayurvedic preparations. International journal of research in pharmaceutical sciences (madurai, india), 2012, vol. 3, no. 4), 670-67, p. 8 pp.
Phua, D. H., Cham, G., Seow, E. Two instances of Chinese herbal medicine poisoning in Singapore. Singapore medical journal, 2008, vol. 49, no. 5, p. E131-E133.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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