Botanical species · safety record

Datura stramonium

The EFSA Compendium of Botanicals holds 1 constituent measurement, 8 adverse-effect records and 1 genotoxicity assay for Datura stramonium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Datura stramonium L.

1Constituent measurements

9Safety records

9Cited sources

2Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Datura stramonium as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Aerial parts
Whole plant with fruit and flower

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Tropane alkaloids	Seed	Solvent extraction	—	Unspecified	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	—	Flowering top	—	Human (as organism)	Case report	Resolve DOI
Systemic	—	—	—	Human (as organism)	Case report	Resolve DOI
Systemic	Neurologic	—	—	Human (as organism)	Case report	Resolve DOI
Systemic	Neurologic	Seed	—	Human (as organism)	Case report	Resolve DOI
Neurotoxicity	Neurologic	Aerial part of plants	—	Horse (as animal)	Case report	No resolvable identifier
Systemic	Digestive	Seed	—	Horse (as animal)	Case report	No resolvable identifier
Systemic	Neurologic	Aerial part of plants	—	Human (as organism)	Case report	No resolvable identifier
Not stated	Neurologic	Leaves	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Ambiguous	—	not reported	Salmonella typhimurium (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Krenzelok, Edward P. Aspects of Datura poisoning and treatment. Clinical toxicology, 2010, vol. 48, no. 2, p. 104-110. DOI
FRIEDMAN, M., HENIKA, PR. MUTAGENICITY OF TOXIC WEED SEEDS IN THE AMES TEST - JIMSON WEED (DATURA-STRAMONIUM), VELVETLEAF (ABUTILON-THEOPHRASTI), MORNING GLORY (IPOMOEA SPP.), AND SICKLEPOD (CASSIA-OBTUSIFOLIA). Journal of agricultural and food chemistry, 1991, vol. 39, no. 3, p. 494-501. DOI
Sever, M., Cekin, M. ANTICHOLINERGIC INTOXICATION DUE TO DATURA STRAMONIUM: THREE PEDIATRIC CASES. Eurasian journal of emergency medicine, 2007, vol. 6, no. 4, p. 28-30.
Schulman, ML., Bolton, LA. Datura seed intoxication in two horses. Journal of the south african veterinary association-tydskrif van die suid-afrikaanse veterinere vereniging, 1998, vol. 69, no. 1, p. 27-29.
Rakotomavo, Falihery., Andriamasy, Caroline., Rasamoelina, Ndrantoniaina., Raveloson, Nasolotsiry. Datura stramonium intoxication in two children. Pediatrics international, 2014, vol. 56, no. 3, p. e14-e16. DOI
Rachid, A., Bouhdadi, S., Salimi, S., Dehbi, F. Datura stramonium poisoning in children Intoxication au Datura stramonium chez l'enfant. Annales de toxicologie analytique, 2013, vol. 25, no. 4, p. 191-193. DOI
Hamouda, C., Amamou, M., Thabet, H., Yacoub, M., Hedhili, A., Bescharnia, F., Ben Salah, N., Zhioua, M., Abdelmoumen, S., Ben Brahim, NE. Plant poisonings from herbal medication admitted to a Tunisian toxicologic intensive care unit, 1983-1998 . Veterinary and human toxicology, 2000, vol. 42, no. 3, p. 137-141.
Bernadet, P., Guegan Le Souder, A., Dondia, D., Titier, K., Courtois, A., Labadie, M. Datura stramonium poisoning: Specific treatment by physostigmine a case report Intoxication au Datura stramonium: Traitement sp�cifique par physostigmine � partir d'un cas. Journal europeen des urgences et de reanimation, 2015, vol. 27, no. 2, p. 113-116. DOI
Gerber, R., Naude, T. W., de Kock, S. S. Confirmed Datura poisoning in a horse most probably due to D. ferox in contaminated tef hay. Journal of the south african veterinary association-tydskrif van die suid-afrikaanse veterinere vereniging, 2006, vol. 77, no. 2, p. 86-89.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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