Botanical species · safety record

Dictamnus albus

The EFSA Compendium of Botanicals holds 38 constituent measurements, 1 adverse-effect record and 3 genotoxicity assays for Dictamnus albus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Dictamnus albus L.

38Constituent measurements

4Safety records

14Cited sources

2Licensed products (Canada)

Also recorded as

Dictamnus albus subsp. caucasicus (Fisch. & C.A.Mey.) N.A.Winter
Dictamnus angustifolius G.Don ex Sweet

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2 licensed products naming Dictamnus albus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Auraptene	Aerial part of plants	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Bergapten	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarins	Aerial part of plants	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Dictamnine	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Dictamnine	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Dictamnine	Roots and other underground parts	Solvent extraction	—	—	Resolve DOI
Dictamnine	Roots and other underground parts	Solvent extraction	≤ 1.67 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Dictamnine	Roots and other underground parts	Solvent extraction	≥ 0.21 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Haplopine	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Methoxsalen	Aerial part of plants	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Psoralen	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Quinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Skimmianine	Aerial part of plants	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Umbelliferone	Aerial part of plants	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Angustifoline	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Dictamnine	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Dictamnine	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Dictamnine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Fraxinellon	Roots and other underground parts	Sap	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Furoquinoline alkaloids	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Gamma fagarine	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Gamma fagarine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Gamma fagarine	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Herniarin	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Limonoids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Limonoids	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Obacunone	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Robustine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Robustine	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Scopoletin	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Skimmianine	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Skimmianine	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier
Umbelliferone	Roots and other underground parts	Solvent extraction	—	Chromatography hyphenated to element spectrometry	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Roots and other underground parts	Solvent extraction	Human (as organism)	Not reported	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI
Positive	—	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	With	No resolvable identifier
No data	gene mutation	bacterial reverse mutation assay	Salmonella typhimurium (as organism)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

M�ller, H. Phototoxicity of Dictamnus alba. Contact dermatitis, 1978, vol. 4, no. 5, p. 264-269. DOI
KANAMORI, H., SAKAMOTO, I., MIZUTA, M. FURTHER STUDY ON MUTAGENIC FUROQUINOLINE ALKALOIDS OF DICTAMNI RADICIS CORTEX - ISOLATION OF SKIMMIANINE AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS . Chemical & pharmaceutical bulletin, 1986, vol. 34, no. 4, p. 1826-1829.
Klier, B., Schimmer, O. Microsomal metabolism of dictamnine: identification of metabolites and evaluation of their mutagenicity in Salmonella typhimurium . Mutagenesis, 1999, vol. 14, no. 2, p. 181-185. DOI
Mizuta, Mari., Kanamori, Hisayuki. Mutagenic activities of dictamnine and gamma-fagarine from Dictamni radicis cortex (Rutaceae). Mutation research letters, 1985, vol. 144, no. 4, p. 221-5.
Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. Phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509-512.
Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . Archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119-1124. DOI
Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . Biochemical systematics and ecology, 2013, vol. 50, p. 62-64. DOI
Sun, Jianbo., Jiang, Neng., Lv, Mengying., Tang, Benqin., Wang, Pei., Liang, Jingyu., Chen, Li. Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius. Rsc advances, 2016, vol. 6, no. 27, p. 22550-22554.
Sun, Jian-Bo., Qu, Wei., Wang, Pei., Wu, Fei-Hua., Wang, Li-Ying., Liang, Jing-Yu. Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity. Fitoterapia, 2013, vol. 90, p. 209-213.
Wang, Daijie., Lin, Yunliang., Lin, Xiaojing., Geng, Yanling., Wang, Xiao., Zhang, Jinjie., Qiu, Jiying. EXTRACTION AND ISOLATION OF DICTAMNINE, OBACUNONE AND FRAXINELLONE FROM Dictamnus dasycarpus TURCZ. BY SUPERCRITICAL FLUID EXTRACTION AND HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY . Quimica nova, 2012, vol. 35, no. 2, p. 337-340.
Zou, Pingping., Tu, Pengfei., Jiang, Yong. A simple and specific quantitative method for determination of dictamnine in Dictamni Cortex by H-1 NMR spectroscopy . Analytical methods, 2013, vol. 5, no. 4, p. 1062-1067. DOI
jangjongsun., seoyigeun., hanceol., caehyibog., gimsunje., ijaedong., wangjunho. Four cases of toxic liver injury associated with Dictamnus dasycarpus. Clinical and molecular hepatology, 2008, vol. 14, no. 2, p. 206-212.
Jung, HJ., Sok, DE., Kim, YH., Min, BS., Lee, JP., Bae, KH. Potentiating effect of obacunone from Dictamnus dasycarpus on cytotoxicity of microtuble inhibitors, vincristine, vinblastine and taxol . Planta medica, 2000, vol. 66, no. 1, p. 74-76.
Sun, Jian-bo., Qu, Wei., Guan, Fu-qin., Li, Lin-zhen., Liang, Jing-yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius. Zhongguo tianran yaowu, 2014, vol. 12, no. 3, p. 222-224.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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