Botanical species · safety record

Digitalis ferruginea

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 genotoxicity assay for Digitalis ferruginea. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Digitalis ferruginea L.

11Constituent measurements

1Safety records

7Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cardiac glycosides	Seed	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
P-coumaric acid	Aerial part of plants	Solvent extraction	0.24 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Anthraquinones	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	≤ 62 Percent	Unspecified	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	≥ 40 Percent	Unspecified	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	≤ 24 Percent	Unspecified	No resolvable identifier
Cardenolides	Leaves	Solvent extraction	≥ 19 Percent	Unspecified	No resolvable identifier
Cardiac glycosides	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Digitoxin	Leaves	Solvent extraction	260 Microgram/gram	Radio Immunoassay Tests (RIA)	No resolvable identifier
Digoxin	Leaves	Solvent extraction	22 Microgram/gram	Radio Immunoassay Tests (RIA)	No resolvable identifier
Saponin glycosides	Seed	Solvent extraction	4.89 Percent	Unspecified	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	somatic mutation assay in Drosophila	Drosophila melanogaster (as animal)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Imre, S., Tulus, R., Sengun, I. Flavone and anthraquinone dyes of the digitalis type. IV. Two new anthraquinone compounds from Digitalis ferruginea. Tetrahedron letters, 1971, vol. (48), p. 4681-3.
Katanic, J., Ceylan, R., Matic, S., Boroja, T., Zengin, G., Aktumsek, A., Mihailovic, V., Stanic, S. Novel perspectives on two Digitalis species: Phenolic profile, bioactivity, enzyme inhibition, and toxicological evaluation . South african journal of botany, 2017, vol. 109, p. 50-57. DOI
ULUBELEN, A. PAPER CHROMATOGRAPHIC SEPARATION AND COLORIMETRIC ESTIMATION OF GLYCOSIDES OF DIGITALIS FERRUGINEA SEEDS . Journal of pharmaceutical sciences, 1962, vol. 51, no. 1, p. 62-&. DOI
Calis, I., Akbay, P., Kuruuzum, A., Yalcin, FN., Sahin, P., Pauli, GF. Phenylethanoid and cardioactive glycosides from Digitalis ferruginea. Pharmazie, 1999, vol. 54, no. 12, p. 926-930.
Dordevic, Sinisa., Stankovic, Mihajlo., Stankovic, Slobodan., Stojanovic, Ostoja. Possibility of preparative of pure glycosides from ferruginous digitalis extraction (Digitalis ferruginea L.) leaves. Hemijska industrija, 1980, vol. 34, no. 12, p. 340-6.
Bylka, Wieslawa., Ellnain-Wojtaszek, Maria., Kowalewski, Zdzislaw., Skrzypczakowa, Lutoslawa. Digitonin content in seeds of some species of the Digitalis genus. Herba polonica, 1976, vol. 22(3-4), p. 239-42.
HAGIMORI, M., MATSUMOTO, T., KISAKI, T. STUDIES ON THE PRODUCTION OF DIGITALIS CARDENOLIDES BY PLANT-TISSUE CULTURE .1. DETERMINATION OF DIGITOXIN AND DIGOXIN CONTENTS IN 1ST AND 2ND PASSAGE CALLI AND ORGAN RE-DIFFERENTIATING CALLI OF SEVERAL DIGITALIS SPECIES BY RADIOIMMUNOASSAY . Plant and cell physiology, 1980, vol. 21, no. 8, p. 1391-1404.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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