Botanical species · safety record

Dioscorea villosa

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 adverse-effect record for Dioscorea villosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Dioscorea villosa L.

11Constituent measurements

1Safety records

7Cited sources

202Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 202 licensed products naming Dioscorea villosa as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Dioscorea villosa - root
Dried root(s)
Dried underground part(s)
Fresh underground parts collected after flowering
Fruit
New material
Parties aériennes fraîches récoltées au moment de la floraison
Rhizome

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	—	—	13.4 Percent	—	Resolve DOI
Dioscin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Dioscin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Oxalates	—	—	16.28 Milligram/gram	—	Resolve DOI
Saponins	—	—	45.56 Percent	—	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Triterpene saponins	Roots and other underground parts	Solvent extraction	7.27 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Alkaloids	Roots and other underground parts used as staple food	Solvent extraction	—	PTA precipitation	No resolvable identifier
Saponins	Roots and other underground parts used as staple food	Solvent extraction	—	PTA precipitation	No resolvable identifier
Steroidal glycosides	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Tannins	Roots and other underground parts used as staple food	Solvent extraction	—	PTA precipitation	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Nephrotoxicity	Urogenital: kidneys	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Avula, Bharathi., Wang, Yan-Hong., Ali, Zulfiqar., Smillie, Troy J., Khan, Ikhlas A. Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC-ELSD . Biomedical chromatography, 2014, vol. 28, no. 2, p. 281-294. DOI
Okukpe, K.M., Adeloye, A.A., Belewu, M.A., Alii, O.I., Adeyina, O.A., Annongu, A.A. Investigation of phytohormonal potential of some selected tropical plants. Research journal of medicinal plant, 2012, vol. 6, no. 6, p. 425-432. DOI
Roy, A., Geetha, R.V. Preliminary phytochemical screening of the ethanolic extract of Dioscorea villosa tubers and estimation of diosgenin by HPTLC technique. International journal of drug development and research, 2013, vol. 5, no. 3, p. 377-381.
Chao-Chin Hu., Jau-Tien Lin., Shih-Chuan Liu., Deng-Jye Yang. A spirostanol glycoside from wild yam (Dioscorea villosa) extract and its cytostatic activity on three cancer cells . Journal of food and drug analysis, 2007, vol. 15, no. 3, p. 310-315.
Wojcikowsi, Ken., Wohlmuth, Hans., Johnson, David W., Gobe, Glenda. Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways . Food and chemical toxicology, 2008, vol. 46, no. 9, p. 3122-3131. DOI
Yoon, Kee Dong., Chin, Young-Won., Yang, Min Hye., Choi, Janggyoo., Kim, Jinwoong. Application of High-speed Countercurrent Chromatography-Evaporative Light Scattering Detection for the Separation of Seven Steroidal Saponins from Dioscorea villosa . Phytochemical analysis, 2012, vol. 23, no. 5, p. 462-468. DOI
Yoon, Kee Dong., Kim, Jinwoong. Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection . Journal of separation science, 2008, vol. 31, no. 13, p. 2486-2491. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature