Botanical species · safety record

Duboisia leichhardtii

The EFSA Compendium of Botanicals holds 26 constituent measurements and 1 adverse-effect record for Duboisia leichhardtii. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Duboisia leichhardtii (F.Muell.) F.Muell.

26Constituent measurements

1Safety records

8Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Atropine	Leaves	Drying (dehydration)	1.31 Millimol/100 Gramm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Calystegines	Aerial part of plants	Solvent extraction	867 Milligram/kilogram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Calystegines	Leaves	Solvent extraction	—	Element spectroscopy	Resolve DOI
Hyoscyamine	Leaves	Solvent extraction	3.37 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Hyoscyamine	Leaves	Solvent extraction	≥ 6.71 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Hyoscyamine	Leaves	Solvent extraction	≤ 8.86 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Hyoscyamine	Roots and other underground parts	Solvent extraction	≥ 0.53 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Hyoscyamine	Roots and other underground parts	Solvent extraction	≤ 0.86 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Hyoscyamine	Stem / stalk	Solvent extraction	2.86 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Littorine	Leaves	Solvent extraction	< 1 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Norscopolamine	Leaves	Solvent extraction	< 1 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Scopolamine	Leaves	Solvent extraction	1.08 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Scopolamine	Leaves	Solvent extraction	≥ 3.38 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Scopolamine	Leaves	Solvent extraction	≤ 5.09 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Scopolamine	Leaves	—	8.7 Milligram/gram	UHPLC-MS-MS	Resolve DOI
Scopolamine	Roots and other underground parts	Solvent extraction	≥ 0.06 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Scopolamine	Stem / stalk	Solvent extraction	0.38 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Scopolamine	Roots and other underground parts	Solvent extraction	≤ 1.07 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Scopolamine	Leaves	Drying (dehydration)	9.43 Millimol/100 Gramm	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Tropane alkaloids	Aerial part of plants	Solvent extraction	3.6 Milligram/kilogram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Tropane alkaloids	Leaves	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Alkaloids	Leaves	Solvent extraction	≥ 2.4 Percent	Unspecified	No resolvable identifier
Alkaloids	Leaves	Solvent extraction	≤ 3.1 Percent	Unspecified	No resolvable identifier
Alkaloids	Leaves	Solvent extraction	—	Unspecified	No resolvable identifier
Valtropine	Leaves	Solvent extraction	≥ 0.13 Percent	Unspecified	No resolvable identifier
Valtropine	Leaves	Solvent extraction	≤ 0.4 Percent	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive: pancreas	Leaves	Solvent extraction	—	In vitro	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ullrich, Sophie Friederike., Averesch, Nils J. H., Castellanos, Leonardo., Choi, Young Hae., Rothauer, Andreas., Kayser, Oliver. Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using H-1 NMR-based metabolite profiling and tropane alkaloids-targeted HPLC-MS analysis . Phytochemistry, 2016, vol. 131, p. 44-56. DOI
KITAMURA, Y., SATO, M., MIURA, H. DIFFERENCES OF ATROPINE ESTERASE-ACTIVITY BETWEEN INTACT ROOTS AND CULTURED ROOTS OF VARIOUS TROPANE ALKALOID-PRODUCING PLANTS . Phytochemistry, 1992, vol. 31, no. 4, p. 1191-1194. DOI
Ullrich, Sophie Friederike., Rothauer, Andreas., Hagels, Hansjoerg., Kayser, Oliver. Influence of Light, Temperature, and Macronutrients on Growth and Scopolamine Biosynthesis in Duboisia species . Planta medica, 2017, vol. 83, no. 11, p. 937-945. DOI
Asano, N., Yokoyama, K., Sakurai, M., Ikeda, K., Kizu, H., Kato, A., Arisawa, M., Hoke, D., Drager, B., Watson, AA., Nash, RJ. Dihydroxynortropane alkaloids from calystegine-producing plants. PHYTOCHEMISTRY, 2001, vol. 57, no. 5, p. 721-726. DOI
Kitamura, Y., Tominaga, Y., Ikenaga, T. Winter cherry bugs feed on plant tropane alkaloids and de-epoxidize scopolamine to atropine . Journal of chemical ecology, 2004, vol. 30, no. 10, p. 2085-2090. DOI
Kato, A., Asano, N., Kizu, H., Matsui, K., Suzuki, S., Arisawa, M. Calystegine alkaloids from Duboisia leichhardtii. Phytochemistry, 1997, vol. 45, no. 2, p. 425-429. DOI
ROSENBLUM, EI., TAYLOR, WS. THE ALKALOIDS OF DUBOISIA LEICHHARDTII - BUTROPINE AND VALTROPINE. Journal of pharmacy and pharmacology, 1954, vol. 6, no. 6, p. 410-415.
Griffin, W. J. The alkaloids of Duboisia leichhardtii. Australasian journal of pharmacy, 1965, vol. 46, p. S128-S131.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature