Botanical species · safety record

Ecballium elaterium

The EFSA Compendium of Botanicals holds 6 constituent measurements, 3 adverse-effect records and 2 genotoxicity assays for Ecballium elaterium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ecballium elaterium (L.) A.Rich.

6Constituent measurements

5Safety records

10Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cucurbitacin b	Fruit unspecified	Solvent extraction	2.56 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cucurbitacins	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cucurbitacins	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Cucurbitacine d	Unspecified	—	—	Unspecified	No resolvable identifier
Cucurbitacins	Fruit unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Cucurbitacins	Aerial part of plants	—	—	Chromatographic tests	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Fruit unspecified	—	Human (as organism)	Case report	Resolve DOI
Digestive	Stomach	—	—	—	Case report	No resolvable identifier
Irritation	Skin/subcutis	Seed	—	Human (as organism)	Case report	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	chromosome aberration assay	Other	—	Resolve DOI
Positive	—	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Bizid, Sondes., Sabbah, Meriam., Msakni, Issann., Ben Slimene, Baha., Mohamed, Ghanem., Bouali, Riadh., Ben Abdallah, Hatenn., Abdelli, Nabil. Cholestatic hepatitis due to Ecballium elaterium ingestion. Clinics and research in hepatology and gastroenterology, 2015, vol. 39, no. 5, p. E60-E62. DOI
Perovic, S., Markulin, M. Poisoning with Ecballium elaterium. Paediatria croatica, 1994, vol. 38, no. 1, p. 33-36.
Kocak, Ibrahim., Karabela, Yunus., Karaman, Mehmet., Kaya, Faruk. Late onset diffuse lamellar keratitis as a result of the toxic effect of Ecballium elaterium herb . Journal of refractive surgery, 2006, vol. 22, no. 8, p. 826-827.
VITERBO, A., YAGEN, B., ROSENTHAL, R., MAYER, AM. DEPENDENCE OF ACTIVITY OF CUCURBITACIN IN REPRESSION OF BOTRYTIS LACCASE ON ITS STRUCTURE . Phytochemistry, 1993, vol. 33, no. 6, p. 1313-1315. DOI
Basaran, A. Ahmet., Yu, Tian-Wei., Plewa, Michael J., Anderson, Diana. An investigation of some Turkish herbal medicines in Salmonella typhimurium and in the COMET assay in human lymphocytes. Teratogenesis, carcinogenesis, and mutagenesis, 1996, vol. 16, no. 2, p. 125-138.
Celik, T. A., Aslanturk, O. S. INVESTIGATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF ECBALLIUM ELATERIUM JUICE BASED ON ALLIUM TEST . Methods and findings in experimental and clinical pharmacology, 2009, vol. 31, no. 9, p. 591-596. DOI
Attard, E., Cuschieri, A., Brincat, M.P. Morphological effects induced by Cucurbitacin E on ovarian cancer cells in vitro. Journal of natural remedies, 2005, vol. 5, no. 1, p. 70-74.
Rodriguez Gonzalez, B., Martin Panizo, F. Composition of Ecballium elaterium. II. Separation of free cucurbitacins. Anales de la real sociedad espanola de fisica y quimica, serie b: quimica, 1967, vol. 63(9-10), p. 959-64.
Jacquot, Catherine., Rousseau, Benedicte., Carbonnelle, Delphine., Chinou, Ioanna., Malleter, Marine., Tomasoni, Christophe., Roussakis, Christos. Cucurbitacin-D-induced CDK1 mRNA Up-regulation Causes Proliferation Arrest of a Non-small Cell Lung Carcinoma Cell Line (NSCLC-N6) . Anticancer research, 2014, vol. 34, no. 9, p. 4797-4806.
Agil, A., Miro, M., Jimenez, J., Aneiros, J., Caracuel, MD., Garcia-Granados, A., Navarro, MC. Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium . Planta medica, 1999, vol. 65, no. 7, p. 673-675. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature