Botanical species · safety record

Eleutherococcus senticosus

The EFSA Compendium of Botanicals holds 10 constituent measurements and 2 adverse-effect records for Eleutherococcus senticosus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Eleutherococcus senticosus (Rupr. & Maxim.) Maxim.

10Constituent measurements

2Safety records

5Cited sources

1,757Licensed products (Canada)

Also recorded as

Acanthopanax senticosus (Rupr. & Maxim.) Harms

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 1,757 licensed products naming Eleutherococcus senticosus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid
solid

Source material stated

Dried root(s)
Dried underground part(s)
Eleutherococcus senticosus - root
Fruit
New material
Powder
Racine
Radix

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Eleutheroside b	Unspecified	Solvent extraction	≤ 540.8 Microgram/gram	HPLC-DAD	Resolve DOI
Eleutheroside b	Roots and other underground parts	Solvent extraction	7.63 Percent	Chromatographic tests	Resolve DOI
Furan derivatives	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Indole alkaloids	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Isofraxidin	Unspecified	Solvent extraction	≥ 5.8 Microgram/gram	HPLC-DAD	Resolve DOI
Isofraxidin	Unspecified	Solvent extraction	≤ 27 Microgram/gram	HPLC-DAD	Resolve DOI
Liriodendrin	Roots and other underground parts	Solvent extraction	10.9 Percent	Chromatographic tests	Resolve DOI
Liriodendrin	Unspecified	Solvent extraction	≤ 223.4 Microgram/gram	HPLC-DAD	Resolve DOI
Liriodendrin	Unspecified	Solvent extraction	≥ 66.7 Microgram/gram	HPLC-DAD	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	420.1 Milligram/gram	UV/VIS spectroscopy (photometry)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Leaves	Solvent extraction	—	In vitro	Resolve DOI
Neurotoxicity	Brain	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Wang, Zhi-Bin., Jiang, Hai., Xia, Yong-Gang., Yang, Bing-You., Kuang, Hai-Xue. alpha-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves. MOLECULES, 2012, vol. 17, no. 6, p. 6269-6276. DOI
Zhang, Shuai-nan., li, Xu-zhao., wang, Yu., zhang, Na., yang, Zhi-ming., liu, Shu-min., lu, Fang. Neuroprotection or neurotoxicity? new insights into the effects of Acanthopanax senticosus harms on nervous system through cerebral metabolomics analysis. JOURNAL OF ETHNOPHARMACOLOGY, 2014, vol. 156, p. 290-300. DOI
Dou, Fang., Xi, Miaomiao., Wang, Junxian., Tian, Xiangrong., Hong, Liangjian., Tang, Haifeng., Wen, Aidong. alpha-Glucosidase and alpha-amylase inhibitory activities of saponins from traditional Chinese medicines in the treatment of diabetes mellitus. PHARMAZIE, 2013, vol. 68, no. 4, p. 300-304. DOI
Zhang, Shuai-nan., Li, Xu-zhao., Lu, Fang., Liu, Shu-min. Cerebral potential biomarkers discovery and metabolic pathways analysis of alpha-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics analysis. JOURNAL OF ETHNOPHARMACOLOGY, 2015, vol. 163, p. 264-272. DOI
Li, Q., Jia, Y., Xu, L., Wang, XH., Shen, ZD., Liu, YL., Bi, KS. Simultaneous determination of protocatechuic acid, syringin, chlorogenic acid, caffeic acid, liriodendrin and isofraxidin in Acanthopanax senticosus HARMS by HPLC-DAD. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, vol. 29, no. 3, p. 532-534. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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