Botanical species · safety record

Erythrophleum suaveolens

The EFSA Compendium of Botanicals holds 8 constituent measurements, 4 adverse-effect records and 1 genotoxicity assay for Erythrophleum suaveolens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Erythrophleum suaveolens (Guill. & Perr.) Brenan (Erythrophleum guineense G. Don)

8Constituent measurements
5Safety records
11Cited sources
0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

  • Diterpene alkaloids5
  • Cassaine1
  • Saponins1
  • Tannins1

Plant parts

  • Bark8
  • Leaves3
  • Wood1

Preparations

  • Solvent extraction11
  • Drying (dehydration)1

Effect types

  • Pulmonary and cardiac2
  • Hepatotoxicity1
  • Systemic1

Target tissues

  • Heart2
  • Liver1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
Diterpene alkaloidsBarkSolvent extractionNuclear Magnetic Resonance (NMR)Resolve DOI
TanninsWoodSolvent extractionGC-MSResolve DOI
CassaineBarkSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)No resolvable identifier
Diterpene alkaloidsBarkSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)No resolvable identifier
Diterpene alkaloidsBarkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
Diterpene alkaloidsBarkSolvent extractionStandard Chromatographic tests (paper- thin layer- and column chromatography)No resolvable identifier
Diterpene alkaloidsBarkSolvent extractionNuclear Magnetic Resonance (NMR)No resolvable identifier
SaponinsBarkSolvent extractionUnspecifiedNo resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
Pulmonary and cardiacHeartLeavesSolvent extractionRabbit (as animal)Acute toxicityResolve DOI
Pulmonary and cardiacHeartLeavesSolvent extractionRabbit (as animal)SubchronicResolve DOI
HepatotoxicityLiverBarkSolvent extractionRat (as animal)Short-term toxicityNo resolvable identifier
SystemicLeavesDrying (dehydration)Sheep (as animal)Short-term toxicityNo resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

OutcomeEndpointTestTested organismMetabolic activationSource
Positivechromosome aberrationchromosome aberration assayRat (as animal)Not applicableResolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Friedrich-Fiechtl, J., Spiteller, G. Use of mass spectrum analysis for structure elucidation of alkaloids. X. New alkaloids from Erythrophleum guineense and about Muawin . . Chemische berichte, 1971, vol. 104, no. 11, p. 3335-48.
  2. Saha, Jean-Bosco Tchinda., Abia, Daouda., Dumarcay, Stephane., Ndikontar, Maurice Kor., Gerardin, Philippe., Noah, Joseph Ngamveng., Perrin, Dominique. Antioxidant activities, total phenolic contents and chemical compositions of extracts from four Cameroonian woods: Padouk (Pterocarpus soyauxii Taubb), tali (Erythrophleum suaveolens), moabi (Baillonella toxisperma), and movingui (Distemonanthus benthamianus) . Industrial crops and products, 2013, vol. 41, p. 71-77. DOI
  3. Sowemimo, A. A., Fakoya, F. A., Awopetu, I., Omobuwajo, O. R., Adesanya, S. A. Toxicity and mutagenic activity of some selected Nigerian plants. Journal of ethnopharmacology, 2007, vol. 113, no. 3, p. 427-432. DOI
  4. NWUDE, N., CHINEME, CN. INVESTIGATIONS INTO THE TOXICITY OF THE LEAVES OF ERYTHROPHLEUM-GUINEENSE DON IN SHEEP . Research in veterinary science, 1980, vol. 28, no. 1, p. 112-115.
  5. Ashun, E., Oladimeji-Salami, J., Lartey-Young, G., Appah, J.K.M. Ameliorative effects of tamarind on the toxicity of Erythrophleum suaveolens in rabbits. Toxicology and environmental health sciences, 2017, vol. 9, no. 3, p. 199-208. DOI
  6. CRONLUND, A. NEW ALKALOIDS FROM ERYTHROPHLEUM SPECIES. Planta medica, 1973, vol. 24, no. 4, p. 371-374.
  7. Lindwall, Olle., Sandberg, Finn., Thorsen, Rune., Norin, Torbjorn. Erythrophleguine, a new alkaloid from the bark of Erythrophleum guineense. Tetrahedron letters, 1965, vol. (47), p. 4203-8.
  8. Manfouo, RN., Lontsi, D., Ngounou, FN., Ngadjui, BT., Sondengam, BL. Erythrosuavine, a new diterpenic alkaloid from Erythrophleum suaveolens (Guill. & Perr.) Brenan . Bulletin of the chemical society of ethiopia, 2005, vol. 19, no. 1, p. 69-74.
  9. Akinpelu, B. A., Dare, C. A., Adebesin, F. I., Iwalewa, E. O., Oyedapo, O. O. Effect of stem-bark of Erythrophleum suaveolens (Guill. & Perri.) saponin on fresh water snail (Lanistes lybicus) tissues. African journal of environmental science and technology, 2012, vol. 6, no. 11, p. 446-451.
  10. THORELL, A., AGURELL, S., SANDBERG, F., NORIN, T. 3 NEW ALKALOIDS FROM BARK OF ERYTHROPHLEUM GUINEENSE G DON SYN E SUAVEOLENS (GUILL + PERR) BRENAN . Acta chemica scandinavica, 1968, vol. 22, no. 9, p. 2835-&. DOI
  11. Adisa, Rahmat Adetutu., Nwalioba, Cosmos U., Akujobi, Sylvia., Oribabor, Jude. Sub-Acute Administration of Ethanol Extracts of Erythrophloem suavolens Induced Hepatotoxicity and Oxidative Stress in Wistar Strain Albino Rats . Faseb journal, 2016, vol. 30.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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