Botanical species · safety record

Euphorbia hirta

The EFSA Compendium of Botanicals holds 7 constituent measurements, 2 adverse-effect records and 1 genotoxicity assay for Euphorbia hirta. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Euphorbia hirta L.

7Constituent measurements

3Safety records

5Cited sources

5Licensed products (Canada)

Also recorded as

Chamaesyce hirta (L.) Millsp.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 5 licensed products naming Euphorbia hirta as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Herb
Herb(s)
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Unspecified	Solvent extraction	0.75 Percent	Phytochemical screening	Resolve DOI
Alkaloids	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Cardiac glycosides	Unspecified	Solvent extraction	—	Phytochemical screening	Resolve DOI
Saponins	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Saponins	Unspecified	Solvent extraction	0.55 Percent	Phytochemical screening	Resolve DOI
Tannins	Unspecified	Solvent extraction	11.2 Percent	Phytochemical screening	Resolve DOI
Tannins	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Not reported	—	Leaves	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Hemopoietic	Cardiovascular / haematological	Leaves	Solvent extraction	Rat (as animal)	Short-term toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	No data	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Rajeh, Mohammad Abu Basma., Kwan, Yuet Ping., Zakaria, Zuraini., Latha, Lachimanan Yoga., Jothy, Subramanion L., Sasidharan, Sreenivasan. Acute toxicity impacts of Euphorbia hirta L extract on behavior, organs body weight index and histopathology of organs of the mice and Artemia salina.. Pharmacognosy research, 2012, vol. 4, no. 3, p. 170-7. DOI
Adedapo, Adeolu A., Abatan, Matthew O., Olorunsogo, Olufunso O. Toxic effects of some plants in the genus Euphorbia on haematological and biochemical parameters of rats.. Veterinarski Arhiv, 2004, vol. 74, no. 1, p. 53-62.
Hashemi, S.R., Zulkifli, I., Bejo, M.H., Farida, A., Somchit, M.N. Acute toxicity study and phytochemical screening of selected herbal aqueous extract in broiler chickens. International Journal of Pharmacology, 2008, vol. 4, no. 5, p. 352-360. DOI
Ping, Kwan Yuet., Darah, Ibrahim., Chen, Yeng., Sasidharan, Sreenivasan. Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7 cell line model using comet assay. Asian Pacific Journal of Tropical Biomedicine, 2013, vol. 3, no. 9, p. 692-696. DOI
Khan, Amir Muhammad., Qureshi, Rizwana Aleem., Ullah, Faizan., Gilani, Syed Aneel., Nosheen, Asia., Sahreen, Sumaira., Laghari, Muhammad Khan., Laghari, Muhammad Yousif., Shafiq-Ur-Rehman., Hussain, Ishtiaq., Murad, Waheed. Phytochemical analysis of selected medicinal plants of Margalla Hills and surroundings. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, vol. 5, no. 25, p. 6017-6023. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature