Botanical species · safety record

Euphorbia tirucalli

The EFSA Compendium of Botanicals holds 6 constituent measurements and 1 genotoxicity assay for Euphorbia tirucalli. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Euphorbia tirucalli L.

6Constituent measurements

1Safety records

5Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Lectins	Aerial part of plants	Latex	—	Mass Spectroscopy and hyphenated methods without chromatography	Resolve DOI
Phorbol esters	Aerial part of plants	Solvent extraction	3.12 Microgram/millilitre	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Ingenol esters	Aerial part of plants	Latex	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Phorbol	Aerial part of plants	Latex	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Phorbol esters	Roots and other underground parts	—	—	Unspecified	No resolvable identifier
Scopoletin	Unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Machado MM., Oliveira LF., Zuravski L., Souza RO., Fischer P., Duarte JA., Rocha MO., Guez CM., Boligon AA., Athayde ML. Evaluation of genotoxic and cytotoxic effects of hydroalcoholic extract ofEuphorbia tirucalli (Euphorbiaceae) in cell cultures of human leukocytes.. Anais da Academia Brasileira de Ciencias, 2016. DOI
Wang, Li., Xiao, Guo-qiong., Wang, Yu-fei., Zang, Zhen., Zhao, Yong. Chemical constituents from Euphorbia tirucalli. Tianran chanwu yanjiu yu kaifa, 2014, p. 1961-1964.
F�rstenberger, G., Hecker, E. On the active principles of the euphorbiaceae, XII. Highly unsaturated irritant diterpene esters from Euphorbia tirucalli originating from Madagascar. Journal of natural products, 1986, vol. 49, no. 3, p. 386-397.
Baslas, R. K., Gupta, N. C. Chemical investigation of the root of Euphorbia tirucalli L. Herba hungarica, 1983, p. 35-38.
Santana, Sanzio Silva., Gennari-Cardoso, Margareth Leitao., Carvalho, Fernanda Caroline., Roque-Barreira, Maria Cristina., Santiago, Andre da Silva., Alvim, Fatima Cerqueira., Pirovani, Carlos Priminho. Eutirucallin, a RIP-2 Type Lectin from the Latex of Euphorbia tirucalli L. Presents Proinflammatory Properties . Plos one, 2014, vol. 9, no. 2. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature