Botanical species · safety record

Eurycoma longifolia

The EFSA Compendium of Botanicals holds 26 constituent measurements and 3 adverse-effect records for Eurycoma longifolia. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Eurycoma longifolia Jack

26Constituent measurements

3Safety records

7Cited sources

450Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 450 licensed products naming Eurycoma longifolia as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Aged bark
Branch bark
Dried root extract
Fruit extract
Fruit fibre
New material
Plante entière
Racine

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Carboline alkaloids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Carboline alkaloids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Eurycomanol	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Eurycomanol	Roots and other underground parts	Drying (dehydration)	9.54 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Eurycomanone	Roots and other underground parts	Drying (dehydration)	14.49 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Eurycomanone	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Eurycomanone	Roots and other underground parts	Solvent extraction	14.49 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Indole alkaloids	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Indole alkaloids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Lignans	Stem / stalk	Solvent extraction	—	Phytochemical screening	Resolve DOI
Neolignans	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Quassinoids	Roots and other underground parts	Drying (dehydration)	7.39 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Quassinoids	Roots and other underground parts	Drying (dehydration)	0.72 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Quassinoids	Roots and other underground parts	Powder	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Quassinoids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Quassinoids	Roots and other underground parts	Solvent extraction	32.1 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Live plants	Solvent extraction	—	Phytochemical screening	Resolve DOI
Eurycomanol	Roots and other underground parts	Solvent extraction	≥ 0.46 Percent	LC-MS	No resolvable identifier
Eurycomanol	Roots and other underground parts	Solvent extraction	≤ 2.75 Percent	LC-MS	No resolvable identifier
Eurycomanone	Roots and other underground parts	Solvent extraction	≥ 5.98 Percent	LC-MS	No resolvable identifier
Eurycomanone	Roots and other underground parts	Solvent extraction	≤ 7.75 Percent	LC-MS	No resolvable identifier
Isoscopoletin	Roots and other underground parts	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Quassinoids	Roots and other underground parts	Solvent extraction	≤ 1.25 Percent	LC-MS	No resolvable identifier
Quassinoids	Roots and other underground parts	Solvent extraction	≥ 1.6 Percent	LC-MS	No resolvable identifier
Quassinoids	Roots and other underground parts	Solvent extraction	≤ 2.33 Percent	LC-MS	No resolvable identifier
Quassinoids	Roots and other underground parts	Solvent extraction	≥ 0.65 Percent	LC-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Stomach	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Not reported	—	Live plants	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Not reported	—	Live plants	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. Planta medica, 2002, vol. 68, no. 7, p. 662-664. DOI
Tong, Kind Leng., Chan, Kit Lam., AbuBakar, Sazaly., Low, Bin Seng., Ma, Hai Qiu., Wong, Pooi Fong. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. . Plos one, 2015, vol. 10, no. 3, p. e0121752. DOI
Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . Molecules, 2016, vol. 21, no. 3. DOI
Low, Bin-Seng., Das, Prashanta Kumar., Chan, Kit-Lam. Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract of Eurycoma longifolia Jack in Sprague-Dawley Rats . Phytotherapy research, 2014, vol. 28, no. 7, p. 1022-1029. DOI
Ebrahimi Forough., Ibrahim Baharudin., Murugaiyah Vikneswaran., Lam Chan Kit., Teh Chin Hoe. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification. Planta medica, 2017, vol. 83(1-02), p. 172-182.
Chua, Lee Suan., Amin, Nor Amaiza Mohd., Neo, Jason Chun Hong., Lee, Ting Hun., Lee, Chew Tin., Sarmidi, Mohamad Roji., Aziz, Ramlan Abdul. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang) . Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2011, vol. 879, no. 32, p. 3909-3919. DOI
Nguyen, Thanh Tam., Tran, Thi Phuong Thao., Tran, Van Loc., Ngo, Thi Thuy., Nguyen, Duy Nhu., Tran, Van Sung. About the chemical constituents of the roots of Eurycoma longifolia. Tap chi hoa hoc, 2014, vol. 52, no. 1, p. 124-129.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature