Botanical species · safety record

Ferula gummosa

The EFSA Compendium of Botanicals holds 6 constituent measurements and 1 adverse-effect record for Ferula gummosa. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ferula gummosa Boiss.

6Constituent measurements

1Safety records

7Cited sources

0Licensed products (Canada)

Also recorded as

Ferula galbaniflua Boiss. & Bushe

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Seed	Solvent extraction	—	Phytochemical screening	Resolve DOI
Coumarins	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarins	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Coumarins	—	Oleo-gum-resin	22.22 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Alkaloids	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Myrcene	—	Latex	4.6 Percent	Gaschromatography (GC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Pulmonary and cardiac	Heart	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Iranshahi, Mehrdad., Barthomeuf, Chantal., Bayet-Robert, Mathilde., Chollet, Philippe., Davoodi, Davood., Piacente, Sonia., Rezaee, Ramin., Sahebkar, Amirhossein. Drimane-Type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-Resistant Human Breast Cancer Cell Line.. Journal of traditional and complementary medicine, 2014, vol. 4, no. 2, p. 118-25. DOI
Kasaian, Jamal., Mosaffa, Fatemeh., Behravan, Javad., Masullo, Milena., Piacente, Sonia., Ghandadi, Morteza., Iranshahi, Mehrdad. Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins. FITOTERAPIA, 2015, vol. 103, p. 149-154. DOI
Ghannadi, A., Amree, S. Volatile oil constituents of Ferula gummosa Boiss. from Kashan, Iran. JOURNAL OF ESSENTIAL OIL RESEARCH, 2002, vol. 14, no. 6, p. 420-421.
Sayyah, M., Mandgary, A. Anticonvulsant effect of Ferula gummosa root extract against experimental seizures. Iranian Biomedical Journal, 2003, vol. 7, no. 3, p. 139-143.
Sayyah, M., Mandgary, A., Kamalinejad, M. Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. JOURNAL OF ETHNOPHARMACOLOGY, 2002, vol. 82, no. 2-3, p. 105-109. DOI
Adhami, Hamid-Reza., Fitz, Veronika., Lubich, Andrea., Kaehlig, Hanspeter., Zehl, Martin., Krenn, Liselotte. Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss.. PHYTOCHEMISTRY LETTERS, 2014, vol. 10, p. LXXXII-lxxxvii. DOI
Ghorbani, Ahmad., Mohebbati, Reza., Jafarian, Amir Hossein., Vahedi, Mohammad Mandi., Hosseini, Seyed Mahmoud., Soukhtanloo, Mohammad., Sadeghnia, Hamid Reza., Hosseini, Azar. Toxicity evaluation of hydroalcoholic extract of Ferula gummosa root. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2016, vol. 77, p. 35-41. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature