Botanical species · safety record

Ficaria verna

The EFSA Compendium of Botanicals holds 5 constituent measurements and 1 adverse-effect record for Ficaria verna. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Ficaria verna Huds.

5Constituent measurements

1Safety records

5Cited sources

0Licensed products (Canada)

Also recorded as

Ficaria ranunculoides Roth
Ranunculus ficaria L.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pentacyclic triterpene saponins	Roots and other underground parts used as staple food	—	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Protoanemonin	Live plants	Essential oil	1.48 Milligram/gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Saponins	Roots and other underground parts	—	≤ 2.5 Percent	—	No resolvable identifier
Saponins	Roots and other underground parts	—	≥ 2 Percent	—	No resolvable identifier
Saponins	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Unspecified	Solvent extraction	Human (as organism)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Pourrat, A., Pourrat, H. Pilewort, Ficaria ranunculoides. Plantes medicinales et phytotherapie, 1969, p. 288-295.
TEXIER, O., AHOND, A., REGERAT, F., POURRAT, H. A TRITERPENOID SAPONIN FROM FICARIA-RANUNCULOIDES TUBERS. Phytochemistry, 1984, vol. 23, no. 12, p. 2903-2905. DOI
Bonora, A., Botta, B., Menziani-Andreoli, E., Bruni, A. Organ-specific distribution and accumulation of protoanemonin in Ranunculus ficaria L. Biochemie und physiologie der pflanzen, 1988, p. 451-455.
Marston, Andrew., Cabo, Martine., Lubrano, Christian., Robin, Jean-Renaud., Fromageot, Claude., Hostettmann, Kurt. Clarification of the saponin composition of ranunculus ficaria tubers. Natural product communications, 2006, vol. 1, no. 1, p. 27-32.
Yilmaz, Bulent., Yilmaz, Baris., Aktas, Bora., Unlu, Ozan., Roach, Emir Charles. Lesser celandine (pilewort) induced acute toxic liver injury: The first case report worldwide. . World journal of hepatology, 2015, vol. 7, no. 2, p. 285-8. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature