Botanical species · safety record

Fritillaria imperialis

The EFSA Compendium of Botanicals holds 13 constituent measurements and 1 adverse-effect record for Fritillaria imperialis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Fritillaria imperialis L.

13Constituent measurements

1Safety records

8Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Imperialine	Bulb / clove	Solvent extraction	≤ 13.13 Percent	GC-FID-MS	Resolve DOI
Imperialine	Bulb / clove	Solvent extraction	≥ 6.03 Percent	GC-FID-MS	Resolve DOI
Imperialine	Bulb / clove	—	—	Unspecified	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	GC-FID-MS	Resolve DOI
Steroidal alkaloids	Bulb / clove	—	—	IR and Raman Spectroscopy	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Verticine	Bulb / clove	Solvent extraction	≥ 27.76 Percent	GC-FID-MS	Resolve DOI
Verticine	Bulb / clove	Solvent extraction	≤ 38.32 Percent	GC-FID-MS	Resolve DOI
Imperialine	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Bulb / clove	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kooshapur, H., Kalantari, H., Skandari, F. The effect of Fritillaria imperialis bulb extract on the mice liver.. Toxicology letters (shannon), 2003, vol. 144, no. Suppl. 1, p. s101-s101. DOI
Kiani, M., Sefidkon, F., Babaei, A., Naghavi, M.R. Phytochemical profiling of medicinal isosteroidal alkaloids of Iranian Fritillaria spp. (Liliaceae). Industrial crops and products, 2015, vol. 70, p. 451-458. DOI
PAUL, L., BOIT, HG. NEBENALKALOIDE VON FRITILLARIA-IMPERIALIS. Chemische berichte-recueil, 1958, vol. 91, no. 9, p. 1968-1970. DOI
Atta-ur-Rahman., Akhtar, MN., Choudhary, MI., Tsuda, Y., Sener, B., Khalid, A., Parvez, M. New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities . Chemical & pharmaceutical bulletin, 2002, vol. 50, no. 8, p. 1013-1016.
MASTEROVA, I., KETTMANN, V., MAJER, J., TOMKO, J. ISOBAIMONIDINE, A NEW ALKALOID FROM FRITILLARIA IMPERIALIS-L. Archiv der pharmazie, 1982, vol. 315, no. 2, p. 157-164. DOI
Akhtar, MN., Atta-ur-Rahman, A., Choudhary, MI., Sener, B., Erdogan, I., Tsuda, Y. New class of steroidal alkaloids from Fritillaria imperialis. Phytochemistry, 2003, vol. 63, no. 1, p. 115-122. DOI
Atta-Ur-Rahman, Afgan Farooq., Choudhary, M. Iqbal., Gilani, Anwarul Hassan., Shaheen, Farhana., Ali, Rahat Azhar., Noor-E-Ain, Farhana., Sener, Bilge. A new anticholinergic steroidal alkaloid from Fritillaria imperialis of Turkish origin . Planta medica, 1994, vol. 60, no. 4, p. 377-379.
Tsuda, Y., Atta-ur-Rahman., Akhtar, MN., Sener, B., Parvez, M., Sashida, Y., Mimaki, Y., Mizuno, M. The structure of a new crystalline cevane alkaloid: Its identity with persicanidine B and harepermine . Natural product research, 2004, vol. 18, no. 3, p. 205-209. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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