Botanical species · safety record

Fritillaria thunbergii

The EFSA Compendium of Botanicals holds 25 constituent measurements and 2 adverse-effect records for Fritillaria thunbergii. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Fritillaria thunbergii Miq.

25Constituent measurements

2Safety records

7Cited sources

153Licensed products (Canada)

Also recorded as

Fritillaria thunbergii var. chekiangensis P.K.Hsiao & K.C.Hsia

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 153 licensed products naming Fritillaria thunbergii as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Bulb
Bulbus

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Steroidal alkaloids	Bulb / clove	—	18.18 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	708.14 Microgram/gram	GC-MS	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	0.554 Milligram/gram	HPLC-CAD	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	191.7 Microgram/gram	HPLC-ELSD	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	0.797 Milligram/gram	HPLC-CAD	Resolve DOI
Steroidal alkaloids	Bulb / clove	—	4.49 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Steroidal alkaloids	Bulb / clove	—	0.49 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	62.12 Microgram/gram	GC-MS	Resolve DOI
Steroidal alkaloids	Bulb / clove	—	0.58 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	—	HPLC-ELSD	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	147.83 Microgram/gram	GC-MS	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	802.9 Microgram/gram	HPLC-ELSD	Resolve DOI
Verticine	Bulb / clove	Solvent extraction	329.3 Microgram/gram	HPLC-ELSD	Resolve DOI
Verticine	Bulb / clove	—	10.48 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Verticine	Bulb / clove	Solvent extraction	1015.61 Microgram/gram	GC-MS	Resolve DOI
Verticine	Bulb / clove	Solvent extraction	2075.2 Microgram/gram	HPLC-ELSD	Resolve DOI
Zhebeinine	Bulb / clove	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Steroidal alkaloids	Bulb / clove	Solvent extraction	387.4 Microgram/gram	LC-TOF-MS	No resolvable identifier
Steroidal alkaloids	Bulb / clove	Solvent extraction	38.44 Microgram/gram	LC-TOF-MS	No resolvable identifier
Steroidal alkaloids	Bulb / clove	Solvent extraction	5.507 Microgram/gram	LC-TOF-MS	No resolvable identifier
Steroidal alkaloids	Bulb / clove	Solvent extraction	54.48 Microgram/gram	LC-TOF-MS	No resolvable identifier
Verticine	Bulb / clove	Solvent extraction	1.598 Microgram/gram	LC-TOF-MS	No resolvable identifier
Verticine	Bulb / clove	Solvent extraction	105.1 Microgram/gram	LC-TOF-MS	No resolvable identifier
Verticine	Bulb / clove	Solvent extraction	463.9 Microgram/gram	LC-TOF-MS	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Lung	Roots and other underground parts	Solvent extraction	House mouse (as animal)	Acute toxicity	Resolve DOI
Systemic	Neurologic: central nervous system	Roots and other underground parts	Solvent extraction	Rat (as animal)	Chronic/long term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . Journal of chromatography a, 2001, vol. 909, no. 2, p. 207-214. DOI
Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. Journal of chromatography a, 2008, vol. 1177, no. 1, p. 126-137.
Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . Journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174-1179. DOI
Li, SL., Chan, SW., Li, P., Lin, G., Zhou, GH., Ren, YJ., Chiu, FCK. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria . Journal of chromatography a, 1999, vol. 859, no. 2, p. 183-192. DOI
ZHANG, JX., AINA, L., XU, RS. STEROIDAL ALKALOIDS FROM FRITILLARIA-THUNBERGII VAR CHEKIANGENSIS. Phytochemistry, 1993, vol. 33, no. 4, p. 946-947. DOI
Long, Zhen., Guo, Zhimou., Acworth, Ian N., Liu, Xiaoda., Jin, Yan., Liu, Xingguo., Liu, Lvye., Liang, Lina. A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection . Talanta, 2016, vol. 151, p. 239-244. DOI
Li, Zehui., Qiao, Yuan., Li, Jianguo., An, Chao., Hu, Kaiwen., Tang, Minke. Acute and sub-chronic toxicity studies of the extract of Thunberg Fritillary Bulb . Regulatory toxicology and pharmacology, 2014, vol. 68, no. 3, p. 370-377. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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