Botanical species · safety record

Gentiana lutea

The EFSA Compendium of Botanicals holds 11 constituent measurements and 1 genotoxicity assay for Gentiana lutea. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Gentiana lutea L.

11Constituent measurements

1Safety records

5Cited sources

296Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 296 licensed products naming Gentiana lutea as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid

Source material stated

Dried root(s)
Fresh underground part(s)
Gentian Root extract
Gentiana lutea- Root
New material
Racine
Rhizome
Rhizome and root(s)

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Camphor	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Estragole	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Eugenol	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Furan derivatives	Roots and other underground parts	Solvent extraction	—	GC-MS	Resolve DOI
Carboline alkaloids	Unspecified	Solvent extraction	≤ 69.9 Nanogram/gram	HPLC-FD	No resolvable identifier
Harman	Unspecified	Solvent extraction	≥ 8.5 Nanogram/gram	HPLC-FD	No resolvable identifier
Harman	Unspecified	Solvent extraction	≤ 11.9 Nanogram/gram	HPLC-FD	No resolvable identifier
Hydroxymethylfurfural	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Norharmane	Unspecified	Solvent extraction	≥ 66.6 Nanogram/gram	HPLC-FD	No resolvable identifier
Norharmane	Unspecified	Solvent extraction	≤ 77.4 Nanogram/gram	HPLC-FD	No resolvable identifier
Venoterpine	Roots and other underground parts	—	—	UV/VIS spectroscopy (photometry)	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Other	gene mutation	other	Drosophila melanogaster (as animal)	Not applicable	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of beta-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. Phytochemical Analysis, 1999, p. 247-253.
Patenkovic, Aleksandra., Stamenkovic-Radak, Marina., Nikolic, Dragana., Markovic, Tamara., Andelkovic, Marko. Synergistic effect of Gentiana lutea L. on methyl methanesulfonate genotoxicity in the Drosophila wing spot test . Journal of ethnopharmacology, 2013, vol. 146, no. 2, p. 632-636. DOI
Mustafa, Ahmed M., Caprioli, Giovanni., Maggi, Filippo., Vittori, Sauro., Sagratini, Gianni. Comparative Analysis of the Volatile Profiles from Wild, Cultivated, and Commercial Roots of Gentiana lutea L. by Headspace Solid Phase Microextraction (HS-SPME) Coupled to Gas Chromatography Mass Spectrometry (GC-MS) . Food analytical methods, 2016, vol. 9, no. 2, p. 311-321. DOI
Amakura, Yoshiaki., Yoshimura, Morio., Morimoto, Sara., Yoshida, Takashi., Tada, Atsuko., Ito, Yusai., Yamazaki, Takeshi., Sugimoto, Naoki., Akiyama, Hiroshi. Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives . Chemical & pharmaceutical bulletin, 2016, vol. 64, no. 1, p. 78-82.
Rulko, Felicja. Isolation and study of the structure of alkaloids from Gentianaceae plants. Prace naukowe akademii medycznej we wroclawiu, 1976, p. 3-36.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature