Botanical species · safety record

Glaucium flavum

The EFSA Compendium of Botanicals holds 17 constituent measurements and 1 adverse-effect record for Glaucium flavum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Glaucium flavum Crantz

17Constituent measurements

1Safety records

6Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Chelidonine	Unspecified	Solvent extraction	650 Microgram/gram	UHPLC-MS-MS	Resolve DOI
Glaucine	Unspecified	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Hernovine	—	Solvent extraction	—	UHPLC-MS-MS	Resolve DOI
Protopine	Aerial part of plants	Solvent extraction	0.08 Percent	HPLC-DAD	Resolve DOI
Protopine	Roots and other underground parts	Solvent extraction	0.84 Percent	HPLC-DAD	Resolve DOI
Protopine	Unspecified	Solvent extraction	4990 Microgram/gram	UHPLC-MS-MS	Resolve DOI
Sanguinarine	Unspecified	Solvent extraction	407.4 Microgram/gram	UHPLC-MS-MS	Resolve DOI
Allocryptopine	Flower	—	—	Chromatographic tests	No resolvable identifier
Glaucine	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Glaucine	Aerial part of plants	—	≤ 20 Microgram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Glaucine	Aerial part of plants	—	≥ 5 Microgram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Isoboldine	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Isocorydine	Flower	—	—	Chromatographic tests	No resolvable identifier
Isoquinoline alkaloids	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Oxoglaucine	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Protopine	Flower	—	—	Chromatographic tests	No resolvable identifier
Thaliporphine	Aerial part of plants	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Other toxicities	—	—	—	House mouse (as animal)	Acute toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Scholar, E. Glaucine. Xpharm: the comprehensive pharmacology reference, 2011, p. 1-4. DOI
Gozler, Tekant., Unluyol, Serpil. Alkaloids from the flowers of Glaucium flavum Crantz (Papaveraceae). Doga bilim dergisi, seri c: tip, 1981, vol. 5, no. 1, p. 25-6.
Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . Phytotherapy research, 1996, vol. 10, no. 1, p. 62-65.
Buzuk, G. N., Lovkova, M. Ya., Grinkevich, N. I. Quantitative determination of glaucine in Glaucium flavum Crantz. by thin-layer chromatography and spectrophotometry. Prikladnaya biokhimiya i mikrobiologiya, 1980, vol. 16, no. 3, p. 432-8.
Bournine, Lamine., Bensalem, Sihem., Wauters, Jean-Noel., Iguer-Ouada, Mokrane., Maiza-Benabdesselam, Fadila., Bedjou, Fatiha., Castronovo, Vincent., Bellahcene, Akeila., Tits, Monique., Frederich, Michel. Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum . International journal of molecular sciences, 2013, vol. 14, no. 12, p. 23533-23544. DOI
Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . Oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872-9369872. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature