Botanical species · safety record

Glehnia littoralis

The EFSA Compendium of Botanicals holds 33 constituent measurements and 1 adverse-effect record for Glehnia littoralis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Glehnia littoralis F.Schmidt ex Miq.

33Constituent measurements

1Safety records

5Cited sources

104Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 104 licensed products naming Glehnia littoralis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Radix
Root
Whole plant(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergamottin	Roots and other underground parts	Drying (dehydration)	≤ 2 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Bergapten	Aerial part of plants	Drying (dehydration)	≥ 8 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Bergapten	Aerial part of plants	Drying (dehydration)	≤ 173 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Bergapten	Roots and other underground parts	Drying (dehydration)	≥ 16 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Bergapten	Roots and other underground parts	Drying (dehydration)	≤ 88 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Falcarindiol	Roots and other underground parts	Drying (dehydration)	≤ 250 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Falcarindiol	Roots and other underground parts	Drying (dehydration)	≥ 124 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Falcarindiol	Aerial part of plants	Drying (dehydration)	≥ 14 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Falcarindiol	Aerial part of plants	Drying (dehydration)	≤ 152 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Imperatorin	Roots and other underground parts	Drying (dehydration)	≤ 1 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Imperatorin	Leaves	Drying (dehydration)	≤ 10 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Isoimperatorin	Roots and other underground parts	Drying (dehydration)	≤ 1 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Phellopterin	Leaves	Drying (dehydration)	≤ 5 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Phellopterin	Roots and other underground parts	Drying (dehydration)	≤ 1 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Psoralen	Aerial part of plants	Drying (dehydration)	≤ 2 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Psoralen	Roots and other underground parts	Drying (dehydration)	≥ 2 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Psoralen	Roots and other underground parts	Drying (dehydration)	≤ 58 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Xanthotoxol	Roots and other underground parts	Drying (dehydration)	≥ 5 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Xanthotoxol	Aerial part of plants	Drying (dehydration)	≤ 21 Milligram/100 gram	HPLC with standard detection methods	Resolve DOI
Xanthotoxol	Roots and other underground parts	Drying (dehydration)	≤ 144 Milligram/100 gram	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Angelicin	Aerial part of plants	Solvent extraction	0.016 Milligram/gram	HPLC with standard detection methods	No resolvable identifier
Coumarins	Roots and other underground parts	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	No resolvable identifier
Coumarins	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Falcarindiol	Roots and other underground parts used as staple food	Solvent extraction	≤ 93.66 Microgram/gram	HPLC-DAD	No resolvable identifier
Falcarindiol	Roots and other underground parts used as staple food	Solvent extraction	≥ 28.65 Microgram/gram	HPLC-DAD	No resolvable identifier
Imperatorin	Roots and other underground parts used as staple food	Solvent extraction	≤ 2.24 Microgram/gram	HPLC-DAD	No resolvable identifier
Imperatorin	Roots and other underground parts used as staple food	Solvent extraction	≥ 0.41 Microgram/gram	HPLC-DAD	No resolvable identifier
Isoimperatorin	Roots and other underground parts used as staple food	Solvent extraction	≥ 0.45 Microgram/gram	HPLC-DAD	No resolvable identifier
Isoimperatorin	Roots and other underground parts used as staple food	Solvent extraction	≤ 3.74 Microgram/gram	HPLC-DAD	No resolvable identifier
Polyacetylene derivatives	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Psoralen	Aerial part of plants	Solvent extraction	0.024 Milligram/gram	HPLC with standard detection methods	No resolvable identifier
Psoralen	Roots and other underground parts	Solvent extraction	0.023 Milligram/gram	HPLC with standard detection methods	No resolvable identifier
Psoralen	Roots and other underground parts used as staple food	Solvent extraction	≥ 3.77 Microgram/gram	HPLC-DAD	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Roots and other underground parts	Solvent extraction	House mouse (as animal)	Other	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Li, Jun., Cheung, Anna W. H., Bi, Cathy W. C., Duan, Ran., Zheng, Ken Y. Z., Huang, Wen., Chen, Ji J., Dong, Tina T. X., Tsim, Karl W. K. Quality evaluation of Radix Glehniae (Glehnia littoralis) by HPLC-DAD: chromatographic fingerprinting and quantitative analysis of the herbs from different regions of China. Asian Journal of Traditional Medicines, 2010, p. 40-48.
Hiraoka, N., Chang, JI., Bohm, LR., Bohm, BA. Furanocoumarin and polyacetylenic compound composition of wild Glehnia littoralis in North America. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2002, vol. 30, no. 4, p. 321-325. DOI
Okuyama, Emi., Hasegawa, Tetsuya., Matsushita, Takamitsu., Fujimoto, Haruhiro., Ishibashi, Masami., Yamazaki, Mikio., Hosokawa, Masakiyo., Hiraoka, Noboru., Anetai, Masaki., Masuda, Takahiro., Takasugi, Mitsuo. Analgesic components of Glehnia root (Glehnia littoralis). Natural medicines, 1998, vol. 52, no. 6, p. 491-501.
Dong, Nguyen Thanh., Bae, KiHwan., Kim, Young Ho., Hwang, Gwi Seo., Heo, Ok Soon., Kim, Se Eun., Kang, Jong Seong. Quantitative determination of psoralen and angelicin from some medicinal herbs by high performance liquid chromatography. Archives of Pharmacal Research, 2003, p. 516-520.
Kitajima, J., Okamura, C., Ishikawa, T., Tanaka, Y. Coumarin glycosides of Glehnia littoralis root and rhizoma. CHEMICAL & PHARMACEUTICAL BULLETIN, 1998, vol. 46, no. 9, p. 1404-1407.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature