Botanical species · safety record

Glycyrrhiza glabra

The EFSA Compendium of Botanicals holds 4 constituent measurements, 7 adverse-effect records and 1 genotoxicity assay for Glycyrrhiza glabra. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Glycyrrhiza glabra L.

4Constituent measurements

8Safety records

5Cited sources

2,298Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 2,298 licensed products naming Glycyrrhiza glabra as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh

Source material stated

Dried rhizome
Dried rhizome and adherent roots
Dried root and rhizome
Dried root(s)
Dried stolons
Glycyrrhiza glabra - Root and stolon
Glycyrrhiza glabra - rhizome
Glycyrrhiza glabra - root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Formononetin	Roots and other underground parts	—	—	Unspecified	Resolve DOI
Glycyrrhizic acid	Roots and other underground parts	Solvent extraction	7.64 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Herniarin	Roots and other underground parts	Solvent extraction	—	—	Resolve DOI
Umbelliferone	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Endocrine	Glandular	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Endocrine	Glandular	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Neurotoxicity	Neurologic	Roots and other underground parts	Solvent extraction	Rat (as animal)	Acute toxicity	Resolve DOI
Reproductive	Urogenital: prostrate	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Reproductive	Urogenital: prostrate	Roots and other underground parts	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Liver	Roots and other underground parts	Solvent extraction	Animals (as animal)	Chronic/long term toxicity	Resolve DOI
Systemic	Liver	Roots and other underground parts	Solvent extraction	Animals (as animal)	Chronic/long term toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	gene mutation	bacterial gene mutation assay	Salmonella typhimurium (as organism)	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Nazari, Somayeh., Rameshrad, Maryam., Hosseinzadeh, Hossein. Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review. Phytotherapy research, 2017, vol. 31, no. 11, p. 1635-1650. DOI
Martinez, A., Ikken, Y., Cambero, MI., Marin, ML., Haza, AI., Casas, C., Morales, P. Mutagenicity and cytotoxicity of fruits and vegetables evaluated by the Ames test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Food science and technology international, 1999, vol. 5, no. 5, p. 431-437. DOI
Kim, Chulwon., Lee, Seok-Geun., Yang, Woong Mo., Arfuso, Frank., Um, Jae-Young., Kumar, Alan Prem., Bian, Jinsong., Sethi, Gautam., Ahn, Kwang Seok. Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model. Cancer letters, 2018, vol. 431, p. 123-141. DOI
Paolini, M., Pozzetti, L., Sapone, A., Cantelli-Forti, G. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases. Life sciences, 1998, vol. 62, no. 6, p. 571-582. DOI
Kaur, Prabhjit., Kumar, Manish., Singh, Bikram., Kumar, Subodh., Kaur, Satwinderjeet. Amelioration of oxidative stress induced by oxidative mutagens and COX-2 inhibitory activity of umbelliferone isolated from Glycyrrhiza glabra L. Asian pacific journal of tropical biomedicine, 2012, vol. 2, no. Suppl. 1, p. S120-S126.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature