Botanical species · safety record

Guatteria gaumeri

The EFSA Compendium of Botanicals holds 1 constituent measurement, 4 adverse-effect records and 3 genotoxicity assays for Guatteria gaumeri. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Guatteria gaumeri Greenm.

1Constituent measurements

7Safety records

5Cited sources

4Licensed products (Canada)

Also recorded as

Annona depressa Baill.
Malmea depressa (Baill.) R. E. Fr.
Mosannona depressa (Baill.) Chatrou

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Guatteria gaumeri as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Bark

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bisbenzylisoquinoline alkaloids	Bark	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Reproductive	Testes	Bark	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	—	Unspecified	—	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Testes	Bark	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Systemic	—	Bark	Solvent extraction	House mouse (as animal)	Short-term toxicity	Resolve DOI

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	sister chromatid exchange assay in mammalian cells	Human (as organism)	With and without	Resolve DOI
Positive	gene mutation	bacterial reverse mutation assay	Bacteria (as organism)	No data	No resolvable identifier
Positive	gene mutation	sister chromatid exchange assay in mammalian cells	Bacteria (as organism)	No data	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

CHAMORRO, G., SALAZAR, M., SALAZAR, S., MENDOZA, T. PHARMACOLOGY AND TOXICOLOGY OF GUATTERIA-GAUMERI. Revista de investigacion clinica-clinical and translational investigation, 1993, vol. 45, no. 6, p. 597-604.
DEHAUSSY, H., TITS, M., ANGENOT, L. GUATTEGAUMERINE, NEW BISBENZYLISOQUINOLINE ALKALOID FROM GUATTERIA-GAUMERI . Planta medica, 1983, vol. 49, no. 1, p. 25-27. DOI
Chamorro, G., Garduno, L., Martinez, E., Madrigal, E., Tamariz, J., Salazar, M. Dominant lethal study of alpha-asarone in male mice. Toxicology letters, 1998, vol. 99, no. 2, p. 71-77. DOI
Chellian, Ranjithkumar., Pandy, Vijayapandi., Mohamed, Zahurin. Pharmacology and toxicology of alpha- and beta-Asarone: A review of preclinical evidence . Phytomedicine, 2017, vol. 32, p. 41-58. DOI
MORALESRAMIREZ, P., MADRIGALBUJAIDAR, E., MERCADERMARTINEZ, J., CASSANI, M., GONZALEZ, G., CHAMORROCEVALLOS, G., SALAZARJACOBO, M. SISTER-CHROMATID EXCHANGE INDUCTION PRODUCED BY INVIVO AND INVITRO EXPOSURE TO ALPHA-ASARONE . Mutation research, 1992, vol. 279, no. 4, p. 269-273. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature