Botanical species · safety record

Gymnema sylvestre

The EFSA Compendium of Botanicals holds 5 constituent measurements and 1 adverse-effect record for Gymnema sylvestre. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Gymnema sylvestre (Retz.) R.Br. ex Sm.

5Constituent measurements

1Safety records

5Cited sources

369Licensed products (Canada)

Also recorded as

Marsdenia sylvestris (Retz.) P.I.Forst.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 369 licensed products naming Gymnema sylvestre as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA

Source material stated

Fresh above ground parts
Fruit
Gymnema sylvestre - leaf
Leaf
Leaf extract
Leaf powder
Leaf/Leaves
Leaves

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pregnane derivatives	Stem / stalk	Solvent extraction	—	Element spectroscopy	Resolve DOI
Saponins	Leaves	—	—	Unspecified	Resolve DOI
Saponins	Leaves	Solvent extraction	≥ 3.9 Percent	—	No resolvable identifier
Saponins	Leaves	Solvent extraction	≤ 9.6 Percent	—	No resolvable identifier
Saponins	Leaves	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Hepatotoxicity	Liver	Leaves	Solvent extraction	Human (as organism)	Case report	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Shiyovich, Arthur., Sztarkier, Ignacio., Nesher, Lior. Toxic Hepatitis Induced by Gymnema sylvestre, a Natural Remedy for Type 2 Diabetes Mellitus. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2010, vol. 340, no. 6, p. 514-517. DOI
Leach, Matthew J. Gymnema sylvestre for diabetes mellitus: A systematic review. Journal of alternative and complementary medicine, 2007, vol. 13, no. 9, p. 977-983. DOI
Liao, Dankui., Xu, Shu., Wei, Tengyou., Sun, Jianhua., Yang, Kedi., Tong, Zhangfa. Technical study of extracting gymnemic acid by ultrasonic wave. Zhongchengyao, 2010, p. 497-499.
Khanna, Venkatesan Gopiesh., Kannabiran, Krishnan. Non-proliferative activity of saponins isolated from the leaves of Gymnema sylvestre and Eclipta prostrata on HepG2 cells-in vitro study. International Journal of Pharmaceutical Sciences and Research, 2010, p. 38-42.
Xu, Rui., Yang, Yu., Zhang, Yang., Ren, Fengxia., Xu, Jinlong., Yu, Nengjiang., Zhao, Yimin. New Pregnane Glycosides from Gymnema sylvestre. Molecules, 2015, vol. 20, no. 2, p. 3050-3066. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature