Botanical species · safety record

Gynostemma pentaphyllum

The EFSA Compendium of Botanicals holds 6 constituent measurements and 4 adverse-effect records for Gynostemma pentaphyllum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Gynostemma pentaphyllum (Thunb.) Makino

6Constituent measurements

4Safety records

5Cited sources

94Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 94 licensed products naming Gynostemma pentaphyllum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Fresh

Source material stated

Aerial parts
Aerial parts extract
Gynostemma pentaphyllum - whole plant
Herb
Herb top
Leaf
Leaf extract
Rhizome

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Furan derivatives	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Gypenoside xlix	Live plants	Solvent extraction	—	—	Resolve DOI
Saponins	Aerial part of plants	Solvent extraction	14.9 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Aerial part of plants	Solvent extraction	6 Percent	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Saponins	Aerial part of plants	Solvent extraction	≤ 0.271 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	≥ 0.085 Percent	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Live plants	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Aerial part of plants	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Aerial part of plants	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Live plants	Solvent extraction	—	In vitro	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295-305. DOI
Chin, Hao-Chen., Chen, Ying-Chun., Chang, Long-Zen. Analysis of Gypenoside Content in Taiwan native Gynostemma pentaphyllum (Thunb.) Makino and Toxicity Test of a Health Product Use Thereof . Bulletin of taichung district agricultural improvement station, 2009, no. 105, p. 23-32.
Yang, Fei., Shi, Haiming., Zhang, Xiaowei., Yang, Haisha., Zhou, Qin., Yu, Liangli (Lucy). Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and alpha-glucosidase inhibitory activities . Food chemistry, 2013, vol. 141, no. 4, p. 3606-3613. DOI
Chiranthanut, Natthakarn., Teekachunhatean, Supanimit., Panthong, Ampai., Khonsung, Parirat., Kanjanapothi, Duangta., Lertprasertsuk, Nirush. Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino . Journal of ethnopharmacology, 2013, vol. 149, no. 1, p. 228-234. DOI
Huang, Tom Hsun-Wei., Tran, Van Hoan., Roufogalis, Basil D., Li, Yuhao. Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells . Toxicology and applied pharmacology, 2007, vol. 218, no. 1, p. 30-36. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature