Botanical species · safety record

Hagenia abyssinica

The EFSA Compendium of Botanicals holds 16 constituent measurements and 1 adverse-effect record for Hagenia abyssinica. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hagenia abyssinica (Bruce) J.F.Gmel

16Constituent measurements

1Safety records

6Cited sources

0Licensed products (Canada)

Also recorded as

Brayera anthelmintica Kunth ex A.Rich.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
(-)-camphor	Flower	Essential oil	2.16 Percent	GC-MS/MS	Resolve DOI
(-)-globulol	Flower	Essential oil	58.57 Percent	GC-MS/MS	Resolve DOI
3,4-dihydroxybenzoic acid	Flower	Solvent extraction	≤ 8.92 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
3,4-dihydroxybenzoic acid	Flower	Solvent extraction	≥ 4.27 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Kosotoxin	Flower	Solvent extraction	≥ 6.1 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Kosotoxin	Leaves	Solvent extraction	5.7 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Kosotoxin	Stem / stalk	Solvent extraction	2.9 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Kosotoxin	Flower	Solvent extraction	≥ 960 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Kosotoxin	Flower	Solvent extraction	≤ 1080 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Kosotoxin	Flower	Solvent extraction	≤ 9.5 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Protokosin	Flower	Solvent extraction	≤ 760 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Protokosin	Flower	Solvent extraction	≥ 720 Microgram/gram	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Tannins	Leaves	Drying (dehydration)	—	Phytochemical screening	Resolve DOI
Tannins	Flower	Drying (dehydration)	—	Phytochemical screening	Resolve DOI
Kosotoxin	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Protokosin	Flower	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Flower	Solvent extraction	Gallus gallus (chicken) (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Nibret, E., Wink, M. Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents . Phytomedicine, 2010, vol. 17, no. 12, p. 911-920. DOI
LOW, G., ROGERS, LJ., BRUMLEY, SP., EHRLICH, D. VISUAL DEFICITS AND RETINOTOXICITY CAUSED BY THE NATURALLY-OCCURRING ANTHELMINTICS, EMBELIA-RIBES AND HAGENIA-ABYSSINICA . Toxicology and applied pharmacology, 1985, vol. 81, no. 2, p. 220-230. DOI
WOLDEMARIAM, TZ., FELL, AF., LINLEY, PA. CHROMATOGRAPHIC AND SPECTROSCOPIC STUDIES ON THE CONSTITUENTS IN MALE AND FEMALE FLOWERS OF HAGENIA-ABYSSINICA . Journal of pharmaceutical and biomedical analysis, 1990, vol. 8, no. 8-12, p. 859-865. DOI
LOUNASMAA, M., WIDEN, CJ., HUHTIKANGAS, A. PHLOROGLUCINOL DERIVATIVES OF HAGENIA-ABYSSINICA. Phytochemistry, 1973, vol. 12, no. 8, p. 2017-2025. DOI
Lounasmaa, Mauri., Widen, C. J., Huhtikangas, Aarre. Phloroglucinol derivatives of Hagenia abyssinica. II. Structure determination of kosotoxin and protokosin. Acta chemica scandinavica, series b: organic chemistry and biochemistry, 1974, vol. B28, no. 10, p. 1200-8.
Mekonnen, Kindu., Glatzel, Gerhard., Sieghardt, Monika. Assessments of Fodder Values of 3 Indigenous and 1 Exotic Woody Plant Species in the Highlands of Central Ethiopia . Mountain research and development, 2009, vol. 29, no. 2, p. 135-142. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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