Botanical species · safety record

Handroanthus impetiginosus

The EFSA Compendium of Botanicals holds 19 constituent measurements and 1 genotoxicity assay for Handroanthus impetiginosus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Handroanthus impetiginosus (Mart. ex DC.) Mattos

19Constituent measurements

1Safety records

8Cited sources

75Licensed products (Canada)

Also recorded as

Tabebuia avellanedae Lorentz ex Griseb.
Tabebuia impetiginosa (Mart. ex. DC.) Standl.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 75 licensed products naming Handroanthus impetiginosus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Aged bark
Bark
Bark (trunk)
Bark extract
Branch bark
Inner bark
Inner bark of stem
Pau-d'arco root bark extract

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Estragole	Bark	Solvent extraction	≤ 8.02 Microgram/gram	GC-MS	Resolve DOI
Estragole	Bark	Solvent extraction	≥ 0.32 Microgram/gram	GC-MS	Resolve DOI
Eugenol	Bark	Solvent extraction	≤ 4.15 Microgram/gram	GC-MS	Resolve DOI
Eugenol	Bark	Solvent extraction	≥ 0.15 Microgram/gram	GC-MS	Resolve DOI
Furanonaphthoquinone i	Bark	Solvent extraction	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	Resolve DOI
Furfural	Bark	Solvent extraction	≤ 2.15 Microgram/gram	GC-MS	Resolve DOI
Furfural	Bark	Solvent extraction	≥ 0.37 Microgram/gram	GC-MS	Resolve DOI
Naphthoquinones	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Oxalic acid	Bark	—	0.21 Gram/100 gram	HPLC with standard detection methods	Resolve DOI
4-hydroxybenzoic acid	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Anthraquinones	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Beta-lapachone	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Beta-lapachone	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Beta-lapachone	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Lapachenole	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Lapachol	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Lapachol	Wood	—	—	—	No resolvable identifier
Lapachol	Wood	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Naphthoquinones	Wood	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	single cell gel/comet assay in mammalian cells for detection of DNA damage	Rat (as animal)	—	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Jeon, Ju-Hyun., Lee, Hoi-Seon. Acaricidal Activity of Tabebuia impetiginosa Bark-Derived Constituent against Domestic and Spider Mites (Arachnida: Acari) . Journal of the korean society for applied biological chemistry, 2011, vol. 54, no. 4, p. 551-557. DOI
Pires, Tania C. S. P., Dias, Maria Ines., Calhelha, Ricardo C., Carvalho, Ana Maria., Queiroz, Maria-Joao R. P., Barros, Lillian., Ferreira, Isabel C. F. R. Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements . Molecules, 2015, vol. 20, no. 12, p. 22863-22871. DOI
Lemos, Odilon A., Sanches, Julio C. M., Silva, Icaro E. F., Silva, Marcio L. A., Vinholis, Adriana H. C., Felix, Mireille A. P., Santos, Raquel A., Cecchi, Andrea O. Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats . Genetics and molecular biology, 2012, vol. 35, no. 2, p. 498-502.
Burnett, Alan R., Thomson, Ronald H. Naturally occurring quinones. X. Quinonoid constituents of Tabebuia avellanedae. Journal of the chemical society [section] c: organic, 1967, vol. (21), p. 2100-4.
Park, BS., Lee, KG., Takeoka, GR. Comparison of three sample preparation methods on the recovery of volatiles from taheebo (Tabebuia impetiginosa Martius ex DC) . Flavour and fragrance journal, 2004, vol. 19, no. 4, p. 287-292. DOI
Pereira, Eliezer Menezes., Machado, Thelma de Barros., Leal, Ivana Correa Ramos., Jesus, Desyree Murta., Damaso, Clarissa Rosa de Almeida., Pinto, Antonio Ventura., Giambiagi-de Marval, Marcia., Kuster, Ricardo Machado., Netto dos Santos, Katia Regina. Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Annals of clinical microbiology and antimicrobials, 2006, vol. 5, p. No pp given.
Linardi, M. da Consolacao F., De Oliveira, M. M., Sampaio, M. R. P. Lapachol derivative active against mouse lymphocytic leukemia P-388. Journal of medicinal chemistry, 1975, vol. 18, no. 11, p. 1159-61.
Zhang, Li., Tatsuno, Takanori., Hasegawa, Isao., Tadano, Takeshi., Ohta, Tomihisa. Furanonaphthoquinones from Tabebuia avellanedae induce cell cycle arrest and apoptosis in the human non-small cell lung cancer cell line A549 . Phytochemistry letters, 2015, vol. 11, p. 9-17. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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