Botanical species · safety record

Harungana madagascariensis

The EFSA Compendium of Botanicals holds 20 constituent measurements and 8 adverse-effect records for Harungana madagascariensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Harungana madagascariensis Lam. ex Poir.

20Constituent measurements

8Safety records

6Cited sources

0Licensed products (Canada)

Also recorded as

Haronga madagascariensis (Lam. ex Poir.) Choisy

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Alkaloids	Bark	Solvent extraction	≤ 1.14 Milligram/100 gram	Phytochemical screening	Resolve DOI
Alkaloids	Bark	Solvent extraction	≥ 0.36 Milligram/100 gram	Phytochemical screening	Resolve DOI
Anthracene derivatives	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Anthraquinones	Bark	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Anthraquinones	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Anthrones	Live plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Cardiac glycosides	Bark	Solvent extraction	—	Phytochemical screening	Resolve DOI
Oxalates	Bark	Solvent extraction	≤ 4.63 Milligram/100 gram	—	Resolve DOI
Oxalates	Bark	Solvent extraction	≥ 3.64 Milligram/100 gram	—	Resolve DOI
Saponins	Bark	Solvent extraction	≥ 0.37 Milligram/100 gram	Phytochemical screening	Resolve DOI
Saponins	Bark	Solvent extraction	≤ 0.48 Milligram/100 gram	Phytochemical screening	Resolve DOI
Alkaloids	Bark	Solvent extraction	≤ 2.45 Percent	—	No resolvable identifier
Alkaloids	Bark	Solvent extraction	≥ 0.6 Percent	—	No resolvable identifier
Anthraquinone	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Anthraquinone	Bark	Solvent extraction	≤ 0.54 Percent	—	No resolvable identifier
Anthraquinone	Bark	Solvent extraction	≥ 0.42 Percent	—	No resolvable identifier
Saponins	Bark	Solvent extraction	≥ 0.38 Percent	—	No resolvable identifier
Saponins	Bark	Solvent extraction	≤ 0.59 Percent	—	No resolvable identifier
Saponins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Tannins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Bark	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Bark	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Bark	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Bark	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Digestive	Digestive	Bark	Solvent extraction	Saccharomyces cerevisiae (as organism)	In vitro	Resolve DOI
Pulmonary and cardiac	Blood coagulation	Bark	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Cardiovascular / haematological	Bark	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI
Systemic	Urogenital	Bark	Solvent extraction	Rat (as animal)	Short-term toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Eze, Fredrick Nwude., Airouyuwa, Osamede Jennifer. Quantitative phytochemical evaluation of stem bark extracts of Harungana madagascariensis. British journal of pharmaceutical research, 2014, vol. 4, no. 17), 2068-207, p. 7 pp.
Kouam, SF., Khan, SN., Krohn, K., Ngadjui, BT., Kapche, DGWF., Yapna, DB., Zareem, S., Moustafa, AMY., Choudhary, MI. alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis . Journal of natural products, 2006, vol. 69, no. 2, p. 229-233. DOI
Akah, P.A. Abortifacient activity of some Nigerian medicinal plants. Phytotherapy Research, 1994, vol. 8, no. 2, p. 106-108.
Etame, R.M.E., Mouokeu, R.S., Ngane, R.A.N., Assam, J.P.A., Masoohe, A.M., Tientcheu, R., Hopogap, M.L., Etoa, F.X. Acute and sub-acute toxicity of Harungana madagascariensis LAM (Hypericaceae) stem bark methanol extract. Journal of applied pharmaceutical science, 2017, vol. 7, no. 3, p. 160-167. DOI
Antia, Bassey Sunday., Ita, Basil Nse., Udo, Uwemedimo Emmanuel. Nutrient Composition and In Vitro Antioxidant Properties of Harungana madagascariensis Stembark Extracts . Journal of medicinal food, 2015, vol. 18, no. 5, p. 609-614. DOI
IINUMA, M., TOSA, H., ITO, T., TANAKA, T., AQIL, M. 2 PRENYLATED ANTHRONES IN HARUNGANA-MADAGASCARIENSIS. Phytochemistry, 1995, vol. 40, no. 1, p. 267-270. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature