Botanical species · safety record

Helichrysum italicum

The EFSA Compendium of Botanicals holds 8 constituent measurements and 2 adverse-effect records for Helichrysum italicum. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Helichrysum italicum (Roth) G.Don

8Constituent measurements

2Safety records

7Cited sources

46Licensed products (Canada)

Also recorded as

Helichrysum italicum subsp. italicum

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 46 licensed products naming Helichrysum italicum as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Herb top flowering

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
1,8-cineole	Aerial part of plants	Solvent extraction	≤ 1.4 Percent	Gaschromatography (GC)	Resolve DOI
Benzofurans	Flower	Drying (dehydration)	< 25 Percent	GC-MS	Resolve DOI
Benzofurans	Flower	Solvent extraction	—	High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)	Resolve DOI
Epoxides	Aerial part of plants	Essential oil	16.8 Percent	GC-MS	Resolve DOI
Neolignans	Leaves	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Esculetin	Flower	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Isoscopoletin	Flower	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier
Scopoletin	Flower	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Live plants	Solvent extraction	—	In vitro	Resolve DOI
Digestive	Digestive	Live plants	Solvent extraction	—	In vitro	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Karasartov, B. S., Kurkin, V. A., Zapesochnaya, G. G. Coumarins and flavonoids of the flowers of Helichrysum italicum. Khimiya prirodnykh soedinenii, 1992, vol. (5), p. 577-579.
Jerkovic, Igor., Rajic, Marina., Marijanovic, Zvonimir., Bilic, Mate., Jokic, Stela. Optimization of supercritical CO2 extraction of dried Helichrysum italicum flowers by response surface methodology: GC-MS profiles of the extracts and essential oil . Separation science and technology, 2016, vol. 51, no. 18, p. 2925-2931. DOI
Laura de la Garza, Ana., Etxeberria, Usune., Pilar Lostao, Maria., San Roman, Belen., Barrenetxe, Jaione., Alfredo Martinez, J., Milagro, Fermin I. Helichrysum and Grapefruit Extracts Inhibit Carbohydrate Digestion and Absorption, Improving Postprandial Glucose Levels and Hyperinsulinemia in Rats . Journal of agricultural and food chemistry, 2013, vol. 61, no. 49, p. 12012-12019. DOI
D'Abrosca, Brigida., Buommino, Elisabetta., D'Angelo, Grazia., Coretti, Lorena., Scognamiglio, Monica., Severino, Valeria., Pacifico, Severina., Donnarumma, Giovanna., Fiorentino, Antonio. Spectroscopic identification and anti-biofilm properties of polar metabolites from the medicinal plant Helichrysum italicum against Pseudomonas aeruginosa . Bioorganic & medicinal chemistry, 2013, vol. 21, no. 22, p. 7038-7046. DOI
Mancini, Emilia., De Martino, Laura., Marandino, Aurelio., Scognamiglio, Maria Rosa., De Feo, Vincenzo. Chemical Composition and Possible in Vitro Phytotoxic Activity of Helichrsyum italicum (Roth) Don ssp. italicum . Molecules, 2011, vol. 16, no. 9, p. 7725-7735. DOI
Rigano, Daniela., Formisano, Carmen., Senatore, Felice., Piacente, Sonia., Pagano, Ester., Capasso, Raffaele., Borrelli, Francesca., Izzo, Angelo A. Intestinal antispasmodic effects of Helichrysum italicum (Roth) Don ssp italicum and chemical identification of the active ingredients . Journal of ethnopharmacology, 2013, vol. 150, no. 3, p. 901-906. DOI
Bianchini, A., Tomi, P., Costa, J., Bernardini, AF. Composition of Helichrysum italicum (Roth) G. Don fil. subsp italicum essential oils from Corsica (France) . Flavour and fragrance journal, 2001, vol. 16, no. 1, p. 30-34. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature