Botanical species · safety record

Helicteres isora

The EFSA Compendium of Botanicals holds 13 constituent measurements and 1 adverse-effect record for Helicteres isora. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Helicteres isora L.

13Constituent measurements

1Safety records

7Cited sources

4Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 4 licensed products naming Helicteres isora as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Cucurbitacin b	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Isocucurbitacin b	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Neolignans	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Neolignans	Fruit unspecified	Solvent extraction	—	Chromatography hyphenated to element spectrometry	Resolve DOI
Saponins	Roots and other underground parts	Solvent extraction	—	Phytochemical screening	Resolve DOI
Alkaloids	Fruit unspecified	—	—	Phytochemical screening	No resolvable identifier
Alkaloids	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Anthraquinone	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Cardiac glycosides	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Dimethyleneberberine	Fruit unspecified	Solvent extraction	1.29 Percent	Phytochemical screening	No resolvable identifier
Saponins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier
Saponins	Fruit unspecified	—	—	Phytochemical screening	No resolvable identifier
Tannins	Bark	Solvent extraction	—	Phytochemical screening	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Neurotoxicity	Neurologic	Bark	Solvent extraction	Rat (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Vijay, Kadam Prasad., Laxman, Bhingare Chandrashekhar., Ashok, Rathi Sandesh., Bansilal, Soni Suraj., Janardhan, Patil Manohar. Pharmacognostical evaluation of fruits of Helicteres isora Linn (Sterculiaceae). Journal of Biological Scientific Opinion, 2013, p. 5-8.
Kumar, G., Sharmila Banu, G., Murugesan, A.G., Rajasekara Pandian, M. Preliminary toxicity and phytochemical studies of aqueous bark extract of Helicteres isora L. International Journal of Pharmacology, 2007, vol. 3, no. 1, p. 96-100.
BEAN, MF., ANTOUN, M., ABRAMSON, D., CHANG, CJ., MCLAUGHLIN, JL., CASSADY, JM. CUCURBITACIN B AND ISOCUCURBITACIN-B - CYTO-TOXIC COMPONENTS OF HELICTERES-ISORA. JOURNAL OF NATURAL PRODUCTS, 1985, vol. 48, no. 3, p. 500-500. DOI
Elanchezhiyan, C., Kumaravel, K., Bhat, Bilal Ahmad., Sethupathty, S. Phytochemical and metabolite fingerprinting of Helictres isora through gas chromatography and mass spectrum analysis. Journal of Pharmacy Research (Mohali, India), 2014, p. 243-247.
Bhavsar, Shefalee K., Singh, Satinder., Giri, Suresh., Jain, Mukul R., Santani, Dev D. Effect of saponins from Helicteres isora on lipid and glucose metabolism regulating genes expression. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 124, no. 3, p. 426-433. DOI
Tezuka, Y., Terazono, M., Kusumoto, TI., Kawashima, Y., Hatanaka, Y., Kadota, S., Hattori, M., Namba, T., Kikuchi, T., Tanaka, K., Supriyatna, S. Helisterculins A and B, two new (7.5 ',8.2 ')-neolignans, and helisorin, the first (6.4 ',7.5 ',8.2 ')-neolignan, from the Indonesian medicinal plant Helicteres isora. HELVETICA CHIMICA ACTA, 1999, vol. 82, no. 3, p. 408-417. DOI
Tezuka, Y., Terazono, M., Kusumoto, TI., Hatanaka, Y., Kadota, S., Hattori, M., Namba, T., Kikuchi, T., Tanaka, K., Supriyatna, S. Helicterins A-F, six new dimeric (7.5 ',8.2 ')-neolignans from the Indonesian medicinal plant Helicteres isora. HELVETICA CHIMICA ACTA, 2000, vol. 83, no. 11, p. 2908-2919. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature