Botanical species · safety record

Helleborus purpurascens

The EFSA Compendium of Botanicals holds 4 constituent measurements and 5 adverse-effect records for Helleborus purpurascens. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Helleborus purpurascens Waldst. & Kit.

4Constituent measurements

5Safety records

4Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Hellebrin	Roots and other underground parts	Solvent extraction	≥ 0.44 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Hellebrin	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Hellebrin	Roots and other underground parts	Solvent extraction	≤ 0.515 Percent	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Steroidal spirostane saponins	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	—	Solvent extraction	Human (as organism)	In vitro	Resolve DOI
Not reported	—	—	—	Guinea pig (as animal)	Acute toxicity	No resolvable identifier
Not reported	—	—	—	Cat (as animal)	Acute toxicity	No resolvable identifier
Not reported	—	—	—	Cat (as animal)	Acute toxicity	No resolvable identifier
Not reported	—	—	—	Guinea pig (as animal)	Acute toxicity	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Paun, Gabriela., Litescu, Simona Carmen., Neagu, Elena., Tache, Andreia., Radu, Gabriel Lucian. Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and alpha-chymotrypsin. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, vol. 29, no. 1, p. 28-34. DOI
Buran, L., Babulova, A. The pharmacology of helleborin and deglucohelleborin, cardiac glycosides from Helleborus purpurascens. Casopis lekaru ceskych, 1963, p. 570-574.
Vorobev, N. E., Dzyuba, N. P. Quantitative determination of corelborin in roots of Helleborus purpurascens. Farmatsevtichnii zhurnal (kiev), 1966, p. 37-40.
Dirsch, V., Lacaille-Dubois, M.-A., Wagner, H. Dracoside, a new steroidal saponin from Helleborus purpurascens. Natural Product Letters, 1994, vol. 4, no. 1, p. 29-33.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

Continue

Independent literature