Botanical species · safety record

Helleborus viridis

The EFSA Compendium of Botanicals holds 5 constituent measurements and 2 adverse-effect records for Helleborus viridis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Helleborus viridis L.

5Constituent measurements

2Safety records

5Cited sources

9Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 9 licensed products naming Helleborus viridis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Root

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Hellebrin	Roots and other underground parts	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Steroidal furostan saponins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Corytuberine	Live plants	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Helleborogenone	Roots and other underground parts	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Magnoflorine	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier
Systemic	Heart	Aerial part of plants	—	Cattle (as animal)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

JOHNSON, CT., ROUTLEDG.JK. SUSPECTED HELLEBORUS VIRIDIS POISONING OF CATTLE. VETERINARY RECORD, 1971, vol. 89, no. 7, p. 202-&.
Slavik, Jiri., Bochorakova, Jitka., Slavikova, Leonora. Occurrence of magnoflorine and corytuberine in some wild or cultivated plants of Czechoslovakia. Collection of Czechoslovak Chemical Communications, 1987, p. 804-811.
Stochmal, Anna., Perrone, Angela., Piacente, Sonia., Oleszek, Wieslaw. Saponins in aerial parts of Helleborus viridis L.. PHYTOCHEMISTRY LETTERS, 2010, vol. 3, no. 3, p. 129-132. DOI
Wissner, W. 14-Hydroxy-3-oxo-1,4,20,22-bufatetraenolide, a new compound from underground organs of Helleborus species. Planta Medica, 1973, p. 201-210.
Colombo, M.L., Tome', F., Servettaz, O., Bugatti, C. Phytochemical evaluation of helleborus species growing in northern Italy. Pharmaceutical biology, 1990, vol. 28, no. 3, p. 219-223. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature