Botanical species · safety record

Heracleum sphondylium

The EFSA Compendium of Botanicals holds 28 constituent measurements and 1 genotoxicity assay for Heracleum sphondylium. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Heracleum sphondylium L.

28Constituent measurements

1Safety records

8Cited sources

6Licensed products (Canada)

Also recorded as

Heracleum sphondylium L. subsp. sibiricum (L.) Simonk.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 6 licensed products naming Heracleum sphondylium as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Source material stated

Plante entière
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Bergapten	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Bergapten	Fruit unspecified	Solvent extraction	≤ 2.63 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Bergapten	Fruit unspecified	Solvent extraction	≥ 1.73 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Bergapten	Fruit unspecified	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Bergapten	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Byakangelicol	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Byakangelicol	Fruit unspecified	Solvent extraction	4.13 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Heraclenin	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Isobergapten	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Isopimpinellin	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Isopimpinellin	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Isopimpinellin	Fruit unspecified	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Phellopterin	Roots and other underground parts	Solvent extraction	—	Gelpermeation, High Performance Thin Layer Chromatography (HPTLC)	Resolve DOI
Phellopterin	Fruit unspecified	Solvent extraction	≤ 1.07 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Phellopterin	Fruit unspecified	Solvent extraction	≥ 0.88 Milligram/gram	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Pimpinellin	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Sphondin	Roots and other underground parts	—	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	Resolve DOI
Apiole	Fruit unspecified	Essential oil	≤ 20.4 Percent	GC-MS	No resolvable identifier
Apiole	Fruit unspecified	Essential oil	≥ 4.7 Percent	GC-MS	No resolvable identifier
Apterin	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Bergapten	Fruit unspecified	Solvent extraction	—	HPLC with standard detection methods	No resolvable identifier
Imperatorin	Fruit unspecified	Solvent extraction	—	HPLC with standard detection methods	No resolvable identifier
Isopimpinellin	Fruit unspecified	Solvent extraction	—	HPLC with standard detection methods	No resolvable identifier
Myrcene	Flower	Essential oil	< 10 Percent	GC-MS	No resolvable identifier
Osthol	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Phellopterin	Fruit unspecified	Solvent extraction	—	HPLC with standard detection methods	No resolvable identifier
Umbelliferone	Fruit unspecified	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier
Xanthotoxol	Fruit unspecified	Solvent extraction	—	HPLC with standard detection methods	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	DNA damage and/or repair	sister chromatid exchange assay in mammalian cells	Human (as organism)	—	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Ciesla, Lukasz., Bogucka-Kocka, Anna., Hajnos, Michal., Petruczynik, Anna., Waksmundzka-Hajnos, Monika. Two-dimensional thin-layer chromatography with adsorbent gradient as method of chromatographic fingerprinting of furanocoumarins for distinguishing selected varieties and forms of Heracleum spp. . Journal of chromatography a, 2008, vol. 1207, no. 1-2, p. 160-168. DOI
Ciesla, Lukasz., Petruczynik, Anna., Hajnos, Michal., Bogucka-Kocka, Anna., Waksmundzka-Hajnos, Monika. Two-Dimensional Thin-Layer Chromatography of Structural Analogs. Part II. Method for Quantitative Analysis of Selected Coumarins in Plant Material . Jpc-journal of planar chromatography-modern tlc, 2008, vol. 21, no. 6, p. 447-452. DOI
Ozek, T., Ozek, G., Baser, KHC., Duran, A. Comparison of the essential oils of three endemic Turkish Heracleum species obtained by different isolation techniques . Journal of essential oil research, 2005, vol. 17, no. 6, p. 605-610.
Fischer, Frederik C., Svendsen, A. Baerheim. Apterin, a common furanocoumarin glycoside in the umbelliferae. Phytochemistry (elsevier), 1976, vol. 15, no. 6, p. 1079-80.
Wawrzynowicz, T., Waksmundzka-Hajnos, M., Bieganowska, M. L. Chromatographic investigations of furocoumarins from Heracleum genus fruits. Chromatographia, 1989, vol. 28(3-4), p. 161-6.
ABEL, G., ERDELMEIER, C., MEIER, B., STICHER, O. ISOPIMPINELLIN A FUROCOUMARIN FROM HERACLEUM-SPHONDYLIUM WITH CHROMOSOME DAMAGING ACTIVITY . Planta medica, 1985, vol. 51, no. 3, p. 250-252. DOI
BORGKARLSON, AK., VALTEROVA, I., NILSSON, LA. VOLATILE COMPOUNDS FROM FLOWERS OF 6 SPECIES IN THE FAMILY APIACEAE - BOUQUETS FOR DIFFERENT POLLINATORS . Phytochemistry, 1994, vol. 35, no. 1, p. 111-119.
Glowniak, K., Matysik, G., Bieganowska, M., Soczewinski, E. Gradient thin-layer chromatography of coumarins and furocoumarins. Chromatographia, 1986, vol. 22(7-12), p. 307-10.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature