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Botanical species · safety record

Hibiscus rosa-sinensis

The EFSA Compendium of Botanicals holds 9 constituent measurements and 11 adverse-effect records for Hibiscus rosa-sinensis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hibiscus rosa-sinensis L.

9Constituent measurements
11Safety records
11Cited sources
8Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 8 licensed products naming Hibiscus rosa-sinensis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

  • Extract Type TBA
  • Fresh

Source material stated

  • Flower
  • New material

What the records describe

Constituents measured

  • Alkaloids2
  • Proanthocyanidins (condensed tannins)2
  • Saponins2
  • Genistein1
  • Isoflavones1
  • Ononin1

Plant parts

  • Leaves12
  • Flower5
  • Aerial part of plants2

Preparations

  • Solvent extraction18

Effect types

  • Reproductive8
  • Hepatotoxicity1
  • Nephrotoxicity1
  • Other toxicities1

Target tissues

  • Urogenital7
  • Digestive: pancreas1
  • Liver1
  • Urogenital: kidneys1

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

SubstancePlant partPreparationConcentrationAnalytical methodSource
GenisteinLeavesSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
IsoflavonesLeavesSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
OnoninLeavesSolvent extraction—High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC)Resolve DOI
Proanthocyanidins (condensed tannins)LeavesSolvent extraction≥ 0.1 Gram/kilogramColorimetry, Spectroscopy (Spectrometry) and PhotometryResolve DOI
Proanthocyanidins (condensed tannins)LeavesSolvent extraction≤ 0.3 Gram/kilogramColorimetry, Spectroscopy (Spectrometry) and PhotometryResolve DOI
AlkaloidsLeavesSolvent extraction≤ 0.67 PercentPhytochemical screeningNo resolvable identifier
AlkaloidsLeavesSolvent extraction≥ 0.35 PercentPhytochemical screeningNo resolvable identifier
SaponinsLeavesSolvent extraction≤ 2.08 PercentPhytochemical screeningNo resolvable identifier
SaponinsLeavesSolvent extraction≥ 1.92 PercentPhytochemical screeningNo resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

EffectTarget tissuePlant partPreparationTest organismTest typeSource
Other toxicitiesDigestive: pancreas———OtherResolve DOI
ReproductiveUrogenitalAerial part of plantsSolvent extractionHouse mouse (as animal)Reproduction toxicityResolve DOI
ReproductiveUrogenitalAerial part of plants—Rat (as animal)Reproduction toxicityResolve DOI
ReproductiveUrogenitalFlowerSolvent extractionRat (as animal)Reproduction toxicityResolve DOI
ReproductiveUrogenitalLeavesSolvent extractionHouse mouse (as animal)Reproduction toxicityResolve DOI
ReproductiveUrogenitalFlowerSolvent extractionRat (as animal)Reproduction toxicityResolve DOI
ReproductiveUrogenitalFlowerSolvent extractionHouse mouse (as animal)Reproduction toxicityResolve DOI
HepatotoxicityLiverLeavesSolvent extractionHouse mouse (as animal)Short-term toxicityNo resolvable identifier
NephrotoxicityUrogenital: kidneysLeavesSolvent extractionHouse mouse (as animal)Short-term toxicityNo resolvable identifier
ReproductiveUrogenitalFlowerSolvent extractionRat (as animal)Reproduction toxicityNo resolvable identifier
Reproductive—FlowerSolvent extraction—Reproduction toxicityNo resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

  1. Krishnaiah, D., Devi, T., Bono, A., Sarbatly, R. Studies on phytochemical constituents of six Malaysian medicinal plants. Journal of medicinal plants research, 2009, vol. 3, no. 2, p. 067-072.
  2. Kholkute, S. D., Mudgal, V., Deshpande, P. J. Screening of indigenous medicinal plants for antifertility potentiality. Planta Medica, 1976, p. 151-155.
  3. Kumar, Dinesh., Kumar, Ajay., Prakash, Om. Potential antifertility agents from plants: A comprehensive review. JOURNAL OF ETHNOPHARMACOLOGY, 2012, vol. 140, no. 1, p. 1-32. DOI
  4. NATH, D., SETHI, N., SINGH, RK., JAIN, AK. COMMONLY USED INDIAN ABORTIFACIENT PLANTS WITH SPECIAL REFERENCE TO THEIR TERATOLOGIC EFFECTS IN RATS. JOURNAL OF ETHNOPHARMACOLOGY, 1992, vol. 36, no. 2, p. 147-154. DOI
  5. Aguilar-Urquizo, E., Sangines-Garcia, J. R., Delgadillo, J. A., Capetillo-Leal, C., Torres-Acosta, J. F. J. The onset of puberty of Pelibuey male hair sheep is not delayed by the short term consumption of Morus alba or Hibiscus rosa-sinensis foliage. LIVESTOCK SCIENCE, 2013, vol. 157, no. 1, p. 378-383. DOI
  6. Nath Purobi., Yadav Arun K. Acute and sub-acute oral toxicity assessment of the methanolic extract from leaves of Hibiscus rosa-sinensis L. in mice. Journal of intercultural ethnopharmacology, 2015, p. 70-73.
  7. Nivsarkar, M., Patel, M., Padh, H., Bapu, C., Shrivastava, N. Blastocyst implantation failure in mice due to nonreceptive endometrium: endometrial alterations by Hibiscus rosa-sinensis leaf extract. CONTRACEPTION, 2005, vol. 71, no. 3, p. 227-230. DOI
  8. Patel, D.K., Prasad, S.K., Kumar, R., Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific Journal of Tropical Biomedicine, 2012, vol. 2, no. 4, p. 320-330. DOI
  9. Kamal, R., Gupta, RS., Lohiya, NK. Plants for male fertility regulation. PHYTOTHERAPY RESEARCH, 2003, vol. 17, no. 6, p. 579-590. DOI
  10. Zhou, Mingdong., Jiang, Yan., Zhao, Cuilan., Li, Kaiyuan. Study of antifertility agent in petroleum extract of Hibiscus rosasinensis L. flower. Yunnan daxue xuebao, ziran kexueban, 1998, p. 170-171.
  11. Tung Thanh Tran., Hinds, Lyn A. Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function. PEST MANAGEMENT SCIENCE, 2012, vol. 69, no. 3, p. 342-354. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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