Botanical species · safety record

Hippomane mancinella

The EFSA Compendium of Botanicals holds 6 constituent measurements and 5 adverse-effect records for Hippomane mancinella. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hippomane mancinella L.

6Constituent measurements

5Safety records

5Cited sources

0Licensed products (Canada)

Regulatory presence

No Health Canada licensed natural health product in the snapshot names this species as a medicinal ingredient under this exact binomial. Absence here means absence from this one register under this one name, not absence from trade, and not a safety verdict.

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Daphnane diterpenes	Trunk	Latex	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Diterpenes	Trunk	Latex	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Alkaloids	Unspecified	—	—	Unspecified	No resolvable identifier
Diterpene esters	Unspecified	—	—	Unspecified	No resolvable identifier
Ellagitannins (hydrolysable tannins)	Stem / stalk	—	—	Unspecified	No resolvable identifier
Ellagitannins (hydrolysable tannins)	Leaves	—	—	Unspecified	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	Latex (as part-nature)	Dog (as animal)	Case report	Resolve DOI
Digestive	Tongue	Fruit unspecified	—	Human (as organism)	Case report	Resolve DOI
Systemic	Digestive	Unspecified	Latex (as part-nature)	Dog (as animal)	Case report	Resolve DOI
Systemic	Heart	Fruit unspecified	—	Human (as organism)	Case report	No resolvable identifier
Not stated	Digestive	Fruit unspecified	—	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Morin, M. Manchineel, a little-known toxic tree. Lyon pharmaceutique, 1985, vol. 36, no. 2, p. 97-101.
Bygbjerg, I C., Johansen, H K. Manchincel poisoning complicated by streptococcal pharyngitis and impetigo . . Ugeskrift for laeger, 1991, vol. 154, no. 1, p. 27-8.
Earle, K.V. Toxic effects of Hippomane mancinella. Transactions of the royal society of tropical medicine and hygiene, 1938, vol. 32, no. 3, p. 363-370. DOI
Sparman, A., John, J., Wills, L. Manchineel poisoning bradyarrhythmia: A possible association. West indian medical journal, 2009, vol. 58, no. 1, p. 65-66.
ADOLF, W., HECKER, E. ON THE ACTIVE PRINCIPLES OF THE SPURGE FAMILY .10. SKIN IRRITANTS, COCARCINOGENS, AND CRYPTIC COCARCINOGENS FROM THE LATEX OF THE MANCHINEEL TREE . Journal of natural products, 1984, vol. 47, no. 3, p. 482-496. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature