Holarrhena pubescens

Also recorded as

• Holarrhena antidysenterica (G.Don) Wall. ex A.DC.

Synonyms are carried from the source compendium. A species may be traded and studied under more than one name, which is exactly how a safety record gets lost.

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 12 licensed products naming Holarrhena pubescens as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

What the records describe

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

1. Ali, Kazi Monjur., Chatterjee, Kausik., De, Debasis., Jana, Kishalay., Bera, Tushar Kanti., Ghosh, Debidas. Inhibitory effect of hydro-methanolic extract of seed of Holarrhena antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat. Journal of ethnopharmacology, 2011, vol. 135, no. 1, p. 194-196. DOI
2. Nahar, U. J., Bhuiyan, M. M. R., Samsudduzah, A. N. M., Uddin, M. R., Maryam, Z. PHYTOCHEMICAL SCREENING, CYTOTOXIC AND CNS DEPRESSANT ACTIVITIES OF HOLARRHENA ANTIDYSENTERICA LEAVES AND SEEDS. International journal of pharmaceutical sciences and research, 2015, vol. 6, no. 2, p. 620-623. DOI
3. Namasudra, S., Phukan, P., Bawari, M. Evaluation of neurotoxicity of the ethanolic bark extract of holarrhena pubescens wall. Ex g.don in mice. International journal of pharmaceutical research, 2020, vol. 12, no. 4, p. 36-48. DOI
4. Singh, Rajendra Kumar. Pre-clinical toxicity studies of Holarrhena antidysentrica stem bark in mice and rats. World journal of pharmacy and pharmaceutical sciences, 2018, vol. 7, no. 4, p. 912-922.
5. Prochazka, Zelimir., Labler, Ludvik., Kotasek, Zdenek. Steroids. XIII. Paper chromatography of steroid amines. Collection of czechoslovak chemical communications, 1954, vol. 19, p. 1258-63.
6. Houghton, PJ., Diogo, MLD. The conessine content of Holarrhena pubescens from Malawi. INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1996, vol. 34, no. 4, p. 305-307.
7. Das, Kuntal., Dang, Raman. Influence of demographic location and solvent extraction on pharmacognostical assessment and identification of conessine content in different parts of Holarrhena antidysentrica through HPTLC analysis. Chaos, 2017, vol. 27, no. 6, p. 427-435.
8. Manika, N., Gupta, Vivek K., Verma, Ram K., Darokar, Mahendra P., Pandey, Nalini., Bagchi, Gurudas. Extraction efficacy, antibacterial potential and validation of RP-HPLC coupled with diode array detection in Holarrhena pubescens. International journal of pharmaceutical sciences and research, 2013, p. 3020-3027.
9. SIDDIQUI, BS., USMANI, SB., BEGUM, S., SIDDIQUI, S., AFTAB, K., GILANI, AUH. HYPOTENSIVE CONSTITUENTS FROM THE BARK OF HOLARRHENA-PUBESCENS (HOLARRHENA-ANTIDYSENTERICA). HETEROCYCLES, 1995, vol. 41, no. 2, p. 267-276.
10. Siddiqui, BS., Usmani, SB., Ali, ST., Begum, S., Rizwani, GH. Further constituents from the bark of Holarrhena pubescens. PHYTOCHEMISTRY, 2001, vol. 58, no. 8, p. 1199-1204. DOI
11. Yang, Zhong-Duo., Duan, Dong-Zhu., Xue, Wei-Wei., Yao, Xiao-Jun., Li, Shuo. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. Life sciences, 2012, vol. 90, no. 23-24, p. 929-933. DOI
12. Kumar, Neeraj., Singh, Bikram., Bhandari, Pamita., Gupta, Ajai Prakash., Kaul, Vijay Kumar. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical & pharmaceutical bulletin, 2007, vol. 55, no. 6, p. 912-914. DOI
13. Kumar, S., Yadav, A. Comparative study of hypoglycemic effect of holarrhena antidysenterica seeds and glibenclamide in experimentally induced diabetes mellitus in albino rats. Biomedical and pharmacology journal, 2015, vol. 8, no. 1, p. 477-483. DOI
14. Bhutani, K. K., Ali, M., Sharma, S. R., Vaid, R. M., Gupta, D. K. Investigations of medicinal plants. Part 10. Three new steroidal alkaloids from the bark of Holarrhena antidysenterica. Phytochemistry, 1988, vol. 27, no. 3, p. 925-8.

Continue