Botanical species · safety record

Hoodia gordonii

The EFSA Compendium of Botanicals holds 6 constituent measurements and 7 adverse-effect records for Hoodia gordonii. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hoodia gordonii (Masson) Sweet ex Decne.

6Constituent measurements

7Safety records

8Cited sources

8Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 8 licensed products naming Hoodia gordonii as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
fluid

Source material stated

Aerial parts
Herb top
Stem
Whole plant

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Pregnane	Unspecified	Solvent extraction	25 Percent	—	Resolve DOI
Pregnane derivatives	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal glycosides	Stem / stalk	Solvent extraction	≤ 1.23 Percent	—	Resolve DOI
Steroidal glycosides	Aerial part of plants	Solvent extraction	—	HPLC with standard detection methods	Resolve DOI
Steroidal glycosides	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI
Steroidal glycosides	Stem / stalk	Solvent extraction	≥ 0.78 Percent	—	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Digestive	Unspecified	—	Rat (as animal)	Acute toxicity	Resolve DOI
Endocrine	Glandular	Unspecified	Solvent extraction	—	In vitro	Resolve DOI
Pulmonary and cardiac	Digestive	Unspecified	Solvent extraction	Human (as organism)	Not reported	Resolve DOI
Pulmonary and cardiac	Heart	Unspecified	—	Human (as organism)	Not reported	Resolve DOI
Reproductive	Digestive	Aerial part of plants	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	—	Aerial part of plants	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI
Reproductive	Uterus	Aerial part of plants	Solvent extraction	House mouse (as animal)	Reproduction toxicity	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Dent, M. P., Wolterbeek, A. P. M., Russell, P. J., Bradford, R. Safety profile of Hoodia gordonii extract: Mouse prenatal developmental toxicity study . Food and chemical toxicology, 2012, vol. 50, p. S20-S25. DOI
Shukla, Y.J., Khan, I.A., Geoffroy, P., Miesch, M., Atta-ur-Rahman. 14beta-hydroxypregnanes from succulent plants belonging to hoodia gordonii and caralluma genus: Extraction, biological activities, and synthesis. Studies in natural products chemistry, 2013, vol. 40, p. 327-358. DOI
Komarnytsky, Slavko., Esposito, Debora., Poulev, Alexander., Raskin, Ilya. Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells . Journal of cellular physiology, 2013, vol. 228, no. 5, p. 1120-1126. DOI
Smith, Carine., Krygsman, Annadie. Hoodia gordonii: To eat, or not to eat. Journal of ethnopharmacology, 2014, vol. 155, no. 2, p. 987-991. DOI
Shukla, Yatin J., Pawar, Rahul S., Ding, Yuanqing., Li, Xing-Cong., Ferreira, Daneel., Khan, Ikhas A. Pregnane glycosides from Hoodia gordonii. Phytochemistry, 2009, vol. 70, no. 5, p. 675-683. DOI
Knight, Tamsin L., Swindells, Chris M., Craddock, Andrew M., Maharaj, Vinesh J., Buchwald-Werner, Sybille., Ismaili, Smail Alaoui., McWilliam, Simon C. Cultivation practices and manufacturing processes to produce Hoodia gordonii extract for weight management products . Food and chemical toxicology, 2012, vol. 50, p. S1-S5. DOI
Avula, Bharathi., Wang, Yan-Hong., Pawar, Rahul S., Shukla, Yatin J., Smillie, Troy J., Khan, Ikhlas A. Identification and structural characterization of steroidal glycosides in Hoodia gordonii by ion-trap tandem mass spectrometry and liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry . Rapid communications in mass spectrometry, 2008, vol. 22, no. 16, p. 2587-2596. DOI
Dall'Acqua, Stefano., Innocenti, Gabbriella. Steroidal glycosides from Hoodia gordonii. Steroids, 2007, vol. 72, no. 6-7, p. 559-568. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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