Botanical species · safety record

Hovenia dulcis

The EFSA Compendium of Botanicals holds 8 constituent measurements and 3 adverse-effect records for Hovenia dulcis. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Hovenia dulcis Thunb.

8Constituent measurements

3Safety records

9Cited sources

34Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 34 licensed products naming Hovenia dulcis as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Source material stated

Fruit
Leaf
New material
Seed
Seed(s)

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Chrysophanol	Unspecified	—	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Gallocatechin	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Isoflavones	Unspecified	Solvent extraction	—	Unspecified	No resolvable identifier
Methyl salicylate	Flower	—	—	GC-MS	No resolvable identifier
Perlolyrine	Seed	—	—	Colorimetry, Spectroscopy (Spectrometry) and Photometry	No resolvable identifier
Saponins	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Saponins	Fruit unspecified	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	No resolvable identifier
Saponins	Roots and other underground parts	Solvent extraction	—	Standard Chromatographic tests (paper- thin layer- and column chromatography)	No resolvable identifier

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Digestive	Liver	Aerial part of plants	Fresh	Cattle (as animal)	Case report	Resolve DOI
Neurotoxicity	Brain	Aerial part of plants	Fresh	Cattle (as animal)	Case report	Resolve DOI
Hepatotoxicity	Liver	Unspecified	Solvent extraction	Human (as organism)	Case report	No resolvable identifier

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Kim, Yun Ji., jeonghyerim., Ryu, Seung Lok., Shim, Jae Won., Kim, Duk Soo., simjeongyeon., bagmunsu. A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis. Pediatric Gastroenterology, Hepatology & Nutrition, 2012, vol. 15, no. 2, p. 111-116.
Yoshikawa, M., Murakami, T., Ueda, T., Matsuda, H., Yamahara, J., Murakami, N. Bioactive saponins and glycosides .4. Four methyl-migrated 16,17-seco-dammarane triterpene glycosides from Chinese natural medicine, Hoveniae Semen Seu Fructus, the seeds and fruit of Hovenia dulcis Thunb: Absolute stereostructures and inhibitory activity on histamine release of hovenidulciosides A(1), A(2), B-1, and B-2. CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, vol. 44, no. 9, p. 1736-1743.
Jiang, Bo-quan., Hu, Shu-fen., Fan, Jie-ping., Mei, Xin-dong. Separation of total isoflavones from Hovenia dulcis by microwave-assisted leaching method under pressure. Nanchang daxue xuebao, gongkeban, 2010, p. 1-5.
Ishida, Haruka., Imayoshi, Yuriko., Osaki, Kazuhiko. Volatile components of Hovenia dulcis Thunberg. Koryo, 2014, p. 57-62.
Wu, Long-huo., Zhang, Jian. The chemical constituents of Hovenia dulcis Thunb. Shizhen guoyi guoyao, 2013, p. 1028-1029.
Bernardi F., Possa MG., Faccin M., Gruchouskei L., Fonseca-Alves CE., Pipole F., de Carvalho LR., Elias F. Spontaneous poisoning by Hovenia dulcis in dairy cattle in Southwest Parana,Brazil.. Tropical animal health and production, 2016, vol. 48, no. 1, p. 211-4. DOI
Park, Man Ki., Park, Jeong Hill., Kim, Yong Chul., Kim, Kyoung Ho. Study on the alkaloidal component of the seed of Hovenia dulcis. Soul taehakkyo yakhak nonmunjip, 1989, p. 41-45.
Murakami, Nobutoshi., Ueda, Tomohiko., Yoshikawa, Masayuki., Matsuda, Hisashi., Yamahara, Johji., Saito, Masayuki., Tanaka, Takaharu. Histamine release inhibitory and alcohol induced muscle relaxation inhibitory constituents from Hoveniae Semen Seu Fructus. Absolute structure of methyl-migrated 16,17-seco-dammarane triterpene glycosides, hovenidulciosides. Tennen yuki kagobutsu toronkai koen yoshishu, 1995, p. 397-402.
Ogihara, Yukio., Inoue, Osamu., Otsuka, Hideaki., Kawai, Kenichi., Tanimura, Takenori., Shibata, Shoji. Droplet counter-current chromatography for the separation of plant products. Journal of Chromatography, 1976, p. 218-223.

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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