Botanical species · safety record

Humulus lupulus

The EFSA Compendium of Botanicals holds 1 constituent measurement, 3 adverse-effect records and 1 genotoxicity assay for Humulus lupulus. This page reports what those source records contain and how to reach them. It carries no effect estimate, no dose and no recommendation.

Accepted name in source: Humulus lupulus L.

1Constituent measurements

4Safety records

3Cited sources

604Licensed products (Canada)

Regulatory presence

Health Canada's Licensed Natural Health Products Database holds 604 licensed products naming Humulus lupulus as a medicinal ingredient, matched on the exact Latin binomial. A licence records that a product met the regulator's requirements for sale in Canada. It is not evidence that the product works.

Extract types on licence

Dry
Extract Type TBA
Fresh
fluid
solid

Source material stated

Cone(s)
Dried female inflorescence
Dried strobile
Female inflorescence (strobile)
Flower
Flower buds
Fresh female inflorescences collected before the seeds have ripened and containing as few seeds as possible
Fruit

What the records describe

Constituents measured

Plant parts

Preparations

Effect types

Target tissues

Recorded constituents

What analytical work has found in this species, at which plant part and preparation. A measured constituent is a fact about material, not about effect.

Substance	Plant part	Preparation	Concentration	Analytical method	Source
Calcium oxalate	Aerial part of plants	Solvent extraction	—	Nuclear Magnetic Resonance (NMR)	Resolve DOI

Recorded adverse effects

Adverse effects reported in the source literature, most often in animal or laboratory models at a stated preparation and dose.

Effect	Target tissue	Plant part	Preparation	Test organism	Test type	Source
Systemic	Glandular: thyroid	Flower	Drying (dehydration)	Rat (as animal)	Subchronic	Resolve DOI
Teratogenic	Urogenital	Cone	Solvent extraction	House mouse (as animal)	Reproduction toxicity	No resolvable identifier
Teratogenic	Urogenital	Cone	Solvent extraction	House mouse (as animal)	Reproduction toxicity	No resolvable identifier

Genotoxicity testing

Outcomes of genotoxicity assays as recorded in the source. A negative assay is a result under those test conditions, not a clearance.

Outcome	Endpoint	Test	Tested organism	Metabolic activation	Source
Positive	chromosome aberration	chromosome aberration assay	Other	With and without	Resolve DOI

Cited sources

The literature the compendium cites for this species. Metatron Health has no relationship with these authors or journals and earns nothing from citing them.

Shao, Yue., Li, Lei., Chong, Li-ming., Xu, Li., Gui, Bo., Liu, Xiang-yun., Zhou, Li., Sun, Zu-yue. Reproductive toxicity of hops extracts to male mice. Shengzhi yu biyun, 2014, vol. 34, no. 5, p. 354-359.
Suzuki, Shigeo., Morimoto-Kobayashi, Yumie., Takahashi, Chika., Taniguchi, Yoshimasa., Katayama, Mikio. Genetic, acute and subchronic toxicity studies of matured hop extract produced by extraction from heat-treated hops. Journal of toxicological sciences, 2018, vol. 43, no. 7-9, p. 473-484. DOI
Frackowiak, Anna., Kozlecki, Tomasz., Skibinski, Przemyslaw., Gawel, Wieslaw., Zaczynska, Ewa., Czarny, Anna., Piekarska, Katarzyna., Gancarz, Roman. Solubility, inhibition of crystallization and microscopic analysis of calcium oxalate crystals in the presence of fractions from Humulus lupulus L.. Journal of crystal growth, 2010, vol. 312, no. 23, p. 3525-3532. DOI

Boundary

A constituent measurement is a fact about material at a stated preparation, not a statement about what that material does in a person. An adverse-effect or genotoxicity record is an observation reported in a source, most often in an animal or laboratory model. Neither is a Metatron Health conclusion about causality, human risk or benefit, and the absence of a record is not proof that a preparation is safe. Nothing here is diagnosis, prescribing or individual medical care.

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Independent literature